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EC number: 266-719-9 | CAS number: 67564-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04.1987 - 08.1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Standard Evaluation Procedure; Report No.: EPA-540/9-85-013 (1985)
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-1 (Hydrolysis)
- GLP compliance:
- yes
Test material
- Reference substance name:
- cis-4-[3-(p-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
- EC Number:
- 266-719-9
- EC Name:
- cis-4-[3-(p-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
- Cas Number:
- 67564-91-4
- Molecular formula:
- C20H33NO
- IUPAC Name:
- (2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
- Details on test material:
- IUCLID4 Test substance: other TS: 14-C Fenpropimorph
Constituent 1
- Specific details on test material used for the study:
- Präparat-Nr. 65/17; specific radioactivity of the phenyl-U-14C-labelled substance: 166.69 MBq/g (purity >98%)
- Radiolabelling:
- yes
Study design
- Analytical monitoring:
- yes
- Buffers:
- Buffer solutions were prepared for each pH-value from deionized water which was cleaned prior to use by pumping through a column (25 cm x 3 cm) filled with charcoal. The following solutions were used:
pH 3.0 - 1 mM potassium hydrogen phthalate
pH 5.0 - 1 mM sodium acetate
pH 7.0 - 1 mM sodium phosphate
pH 9.0 - 1 mM boric acid; 1 mM sodium chloride - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 100 ml glass flasks with glass stoppers, containing 60 ml buffer and 600µl of the diluted stock solution
- Sterilisation method: Buffer solutions were sterilized for 20 min at 121°C by auto-claving
- Measures to exclude oxygen: After cooling down to RT argon was bubbled through the solutions for 10 min for replacing oxygen in order to avoid oxidation and/or radical- reactions.
- If no traps were used, is the test system closed/open: flasks with glass stoppers
- Is there any indication of the test material adsorbing to the walls of the test apparatus? The radioactive material was partially adsorbed to the glass vessels. It was redissolved by rinsing with dichloromethane or traced as 14C-carbondioxide after oxidation. Further radioactive material was adsorbed to the glass stopper of the flasks and could also be redissolved with dichloromethane.
OTHER TEST CONDITIONS
- Adjustment of pH: The pH was measured with a pH- meter (Metrohm E 500; for adjustment see attachment 7.2.) and titrated (with 0.1 M HCl or 0.1 M NaOH) to the desired pH before filling up to the required volume.
Duration of test
- Duration:
- 32 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.93 other: ppm
Results and discussion
- Transformation products:
- no
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 103.2
- pH:
- 3
- Temp.:
- 25 °C
- Duration:
- 32 d
- % Recovery:
- 102.6
- pH:
- 5
- Temp.:
- 25 °C
- Duration:
- 32 d
- % Recovery:
- 83.6
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 32 d
- % Recovery:
- 65.2
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 32 d
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 3
- Temp.:
- 25 °C
- DT50:
- > 32 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 5
- Temp.:
- 25 °C
- DT50:
- > 32 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 32 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 32 d
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- The results of the hydrolysis study at 25°C are summarised in Table 1. At no pH-value hydrolysis products were detected by TLC-analyses. At neutral (pH 7) and alkaline (pH 9) pH values the recovery of the test substance decreased with time due to adsorption effects and the low solubility of the active substance at these pH values. A second peak (besides the test substance) in the TLC chromatograms of samples incubated at pH 3 could be characterised as the hydrochloride-adduct of fenpropimorph. In the rinsing solutions of the glass stoppers of the incubation flasks from solutions incubated at pH 9, besides fenpropimorph another compound was characterised by TLC co-chromatography. This compound had a Rf-value similar to the reference substance BF 421-13. An assessment of the concentration of this compound as a reasonable worst case calculation resulted in amounts up to 7.7% TAR. However, this substance is not considered as a hydrolysis product.
Any other information on results incl. tables
Table 1: Recovery of radioactivity in % during hydrolysis of phenyl-U-14C-labelled fenpropimorph (including rinsing solutions) | ||||
time (d) | pH 3 | pH 5 | pH 7 | pH 9 |
| ||||
0 | 114.1* | 111.1* | 105.9* | 104.1* |
1 | 108.2* | 106.4* | 108.9* | 87.2 |
2 | 105.3* | 102.9* | 101.3* | 91.5* |
4 | 108.1 | 103.1 | 85.1 | 75.1 |
6 | 100.8 | 97.3 | 88.2 | 84.9 |
8 | 97.8 | 96.9 | 88.0 | 84.8 |
11 | 100.1* | 98.3* | 92.7* | 88.7* |
12 | 99.5* | 94.7* | 92.4* | 91.1* |
14 | 105.3 | 103.5 | 94.7 | 83.7 |
15 | 101.5 | 100.6 | 92.2 | 69.2 |
18 | 106.5 | 104.9 | 84.8 | 76.6 |
20 | 105.9 | 100.9 | 83.3 | 78.6 |
21 | 102.6 | 102.1 | 82.8 | 80.2 |
26 | 102.9 | 101.5 | 83.4 | 84.3** |
32 | 104.1* | 104.1* | 86.6* | 70.2* |
*: recovery in aqueous solution + rinsing solution from the glass flasks (6 ml dichloromethane)
**: recovery in aqueous solution + rinsing solution of stoppers + radioactivity adsorbed on glass walls
(determined as 14CO2)
Applicant's summary and conclusion
- Conclusions:
- It can be concluded that fenpropimorph is hydrolytically stable in the whole investigated pH-range (pH 3 to pH 9) at 25°C. No half-lives were calculated.
No hydrolysis studies were carried out with metabolites, because no relevant metabolites appeared.
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