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EC number: 266-719-9 | CAS number: 67564-91-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- April 1987- September 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
- Study type:
- direct photolysis
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-2 (Photodegradation Studies in Water)
- Version / remarks:
- June 1985
- GLP compliance:
- yes
- Remarks:
- study was conducted prior to the implementation of GLP certificates
Test material
- Reference substance name:
- cis-4-[3-(p-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
- EC Number:
- 266-719-9
- EC Name:
- cis-4-[3-(p-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
- Cas Number:
- 67564-91-4
- Molecular formula:
- C20H33NO
- IUPAC Name:
- (2R,6S)-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine
- Details on test material:
- IUCLID4 Test substance: other TS: 14-C Fenpropimorph
Constituent 1
Study design
- Radiolabelling:
- yes
- Remarks:
- phenyl-U-14C-labelled fenpropimorph
- Analytical method:
- gas chromatography
- mass spectrometry
- other: thin layer chromatography
- Buffers:
- 1 mM sodium acetate buffer
- Light source:
- Xenon lamp
- Relative light intensity:
- 100 000
- Details on test conditions:
- The direct photolysis was performed with phenyl-U-14C-labelled fenpropimorph. The specific radioactivity was 166.69 MBq/g (purity >98%). The study was performed at pH 5 (sodium acetate buffer). The active substance is hydrolytically stable at this pH-value. The concentration of the active substance in the sterile aqueous buffer solution was about 9 mg/l. Each 31.5 ml of the sterile solution was transferred to sterile open shallow glass dishes. The boxes were placed under a xenon lamp and sealed with quartz glass covers. The light intensity of the simulated sunlight was about 100.000 lx. The study was carried out for 30 days at 25 +/- 2°C with day and night cycle. Additionally, a dark control was investigated. Since the active substance turned out to be stable upon irradiation, 2% (related to the final volume of the respective solution) of a photosensitising reagent (acetone) were added to further samples and the irradiation procedure was repeated. Samples (content of one glass dish) were taken after 0, 1, 2, 4, 8, 16/15 (samples without/with photosensitising reagent), and 30 days. All samples were irradiated in duplicate to confirm reproducibility.
Duration of test at given test condition
- Duration:
- 30 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 10 other: mg a.i./kg
- Dark controls:
- yes
Results and discussion
% Degradationopen allclose all
- Test condition:
- Direct photolysis
- Test condition:
- Indirect photolysis
- Details on results:
- The results of the tests with and without acetone are compared in Table 7.2/2. Based on TLC analysis and MS identification it was proved that no degradation of the active substance occured. Minor amounts of BF 421-13 (identified by MS analysis) as well as of other unidentified degradation products could be detected. Their amounts did not exceed 10% TAR. However, these impurities were already detected in comparable quantities in the stock solution of the active substance and therefore were no photodegradation products.
Any other information on results incl. tables
Table 7.2/2 Recovery of radioactivity in % after application of phenyl-U-14C-labelled fenpropimorph during aqueous photolysis | ||
Irradiation time | Recovery (% TAR) | |
(d) | Samples without acetone | Samples with acetone |
|
|
|
0 | n.d. | n.d. |
1 | 100.8 | 101.1 |
2 | 107.1 | 94.0 |
4 | 100.8 | 97.9 |
8 | 91.5 | 96.6 |
15/16 * | 91.0 | 91.6 |
30 | 85.4 | 91.6 |
30, dark | 112.7 | 104.6 |
*: without/with acetone
n.d.: not determined
Applicant's summary and conclusion
- Conclusions:
- It can be stated that fenpropimorph is photolytically stable. No photolytical half-life of fenpropimorph was calculated.
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