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EC number: 203-585-2 | CAS number: 108-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- two-generation reproductive toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline and GLP study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 416 (Two-Generation Reproduction Toxicity Study)
- Version / remarks:
- ; Other: EPA OPPTS 870.3800
- Deviations:
- yes
- Remarks:
- : Minor study deviations were noted however these deviations did not adversly effect the quality or integrity of the data or the study outcome.
- GLP compliance:
- yes
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Route of administration:
- oral: drinking water
- Details on mating procedure:
- Male: F0: 70 days, F1: 70 days beginning at weaning
Female: F0: 70 days, F1: 70 days beginning at weaning - Duration of treatment / exposure:
- 70 days prior to mating and throughout mating, gestation and lactation
- Frequency of treatment:
- Continuous
- Details on study schedule:
- Duration of test: 18 months
No. of generation studies: 2 - Remarks:
- Doses / Concentrations:
0, 120, 360, 1000 and 3000 mg/l
Basis: - No. of animals per sex per dose:
- 30/sex/group
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Four groups of male and female Crl:CD SD rats (30/sex/group) were administered resorcinol in drinking water for at least 70 consecutive days prior
to mating. Exposure levels were 0, 120, 360, 1000 and 3000 mg/L for the F0 and F1 generations. The concurrent control group (30/sex/group)
received reversed osmosis purified municipal water. The test article was administered to the offspring selected to become the F1 parental generation following weaning (post natal day 21). The F0 and F1 males continued to receive the test article throughout the mating and through the day of
euthanasia. The F0 and F1 females continued to receive the test article throughout mating, gestation, lactation and through the day of euthanasia. - Statistics:
- All statistical tests were performed using appropriate computing devices or programs.
- Reproductive indices:
- Study was conducted to evaluate the potential adverse effects of resorcinol on the reproductive capabilities, including gonadal function, estrous
cyclicity, mating behaviour, conception, gestation, parturition, lactation and weaning of the F0 and F1 generations. - Offspring viability indices:
- Study was conducted to evaluate the potential adverse effects of resorcinol on the F1 and F2 neonatal survival, growth and development.
- Dose descriptor:
- NOAEL
- Effect level:
- 3 000 mg/L drinking water
- Sex:
- male/female
- Basis for effect level:
- other: no adverse effects observed in highest dose tested
- Dose descriptor:
- NOEL
- Effect level:
- 1 000 mg/L drinking water
- Sex:
- male/female
- Basis for effect level:
- water consumption and compound intake
- Dose descriptor:
- NOAEL
- Effect level:
- 3 000 mg/L drinking water
- Sex:
- male/female
- Basis for effect level:
- other: no adverse effects observed in highest dose tested
- Dose descriptor:
- NOEL
- Effect level:
- 1 000 mg/L drinking water
- Sex:
- male/female
- Basis for effect level:
- water consumption and compound intake
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 3 000 mg/L drinking water
- Sex:
- male/female
- Basis for effect level:
- other: no adverse effects observed in highest dose tested
- Reproductive effects observed:
- not specified
- Conclusions:
- Decreased mean water consumption was noted for the 1000 mg/L (F0 generation only) and 3000 mg/L group F0 and F1 parental animals due to the
poor palatability of water containing the two highest concentrations of Resorcinol. The test article-related decreases in water consumption were not
considered adverse even in the 3000 mg/L group because of the lack of associated effects on food intake and food utilization, which indicated that
homeostasis was uncompromised.
Test article-related reductions in mean body weights and/or body weight gains were observed in both parental generations in the 3000 mg/L group. However, there was no evidence of cumulative effects on mean body weights or body weight gains when evaluated across two generations, nor was
there evidence of gender-related effects or of enhanced sensitivity of females to the test article during gestation and lactation.
Decreased mean cumulative body weight gains were noted in the 3000 mg/L F0 group during the premating period (females) and the entire
generation (males). While no definite trends were apparent in weekly mean body weight gains for these animals, mean body weights were reduced in
the F0 females prior to mating (up to 6.3%), during gestation (up to 5.5%) and throughout lactation (up to 8.4%). Mean body weights were unaffected inthe 3000 mg/L group F0 males. A decreased mean cumulative body weight gain was also noted for the 3000 mg/L group F1 males for the entire
generation, corresponding to decreased (up to 7.1%) mean body weights throughout the generation.
There were no clear effects on mean body weight gains in the 3000 mg/L group F1 females; however, mean body weights were decreased in these
females during lactation (up to 6.1%) and after the lactation period ended (up to 7.0%). These reductions were most likely due to poor palatability of
the drinking water containing 3000 mg Resorcinol/L as evidenced by the correspondingly reduced water consumption recorded for these animals.
Decreased water consumption was noted in F0 and F1 males and females at 3000 mg/L and, to a lesser extent, in F0 males and females at an
exposure level of 1000 mg/L during the pre-mating period. However, there were no effects on mean body weights or body weight gains in the 120,
360 and 1000 mg/L group F0 and F1 males and females. During gestation and lactation, water consumption was decreased in both the F0 and F1
females in the 3000 mg/L group. Water consumption remained decreased for these females after the end of the lactation period. In addition, water
consumption was reduced at an exposure level of 3000 mg/L in the F1 generation during the week following weaning (PND 21-28) when the animals were housed by litter. The test article-related decreases in water consumption were not considered adverse due to the lack of associated effects on
food intake and food utilization, which indicated that homeostasis was uncompromised.
The NOAEL is considered to be 3000 mg Resorcinol/L for parental systemic and offspring toxicity (ca. Average F0 and F1 generation 223 mg/kg/day (males), 304 mg/kg/day (females(premating and gestation)), 660 mg/kg/day (females(lactation)) (F1 generation (males) 245 mg/kg/day and
(females) 295 mg/kg/day, while the NOEL is 1000 mg Resorcinol/L (ca. 86 mg/kg/day (males), 126 mg/kg/day (females(premating and gestation),
and 225 mg/kg/day (females(lactation)) (F1 generation (males) 93 mg/kg/day and (females) 126 mg/kg/day.
Although Resorcinol was known to be readily absorbed and eliminated, blood Resorcinol levels could be detected in some animals in the 3000 mg/L
group. Decreased colloid in the thyroid histopathology, although a non-adverse effect in this study, was observed only in the 3000 mg/L group F0
males. Therefore, the effects of Resorcinol have been appropriately evaluated in this study.
Reference
RM-Freetext:
Although not indicated by the study author, we have concluded that the overall systemic NOEL for males and females is 1000 mg/L based on reduced body weight at 3000 mg/L.
RS-Freetext:
No effects on any of the reproductive parameters
When
expressed on a body weight basis (average F0 and F1 animals), the water
concentrations corresponded to: approximately 0, 11, 31, 86 and 223
mg/kg/day for males over the entire generation; 16, 48, 126 and 304
mg/kg/day for females during premating and gestation; and 28, 85, 225,
and 660 mg/kg/day for females during lactation, respectively.
In
offspring (the F1 generation only), the water concentrations
corresponded to approximately 0,11,33,93 and 245 mg/kg/day in males
while in females 0, 16, 41, 126 and 295 mg/kg/day.
There were no F0 or F1 parental test article-related deaths or clinical
findings during the weekly detailed physical examinations. Reproductive
performance (estrous cycles, mating and fertility indices, number of
days between pairing and coitus, and gestation length) and parturition
in the F0 and F1 animals were unaffected by the test article.
Spermatogenic
endpoints (mean testicular and epididymal sperm numbers and sperm
production rate, motility, progressive motility and morphology) in the
F0 and F1 males were unaffected by the test article. No test
article-related effects were observed on F1 and F2 pup survival or the
general physical condition of the pups during the pre-weaning period. No
test article-related macroscopic findings, organ weight or adverse
microscopic target-organ effects were observed in the F0 or F1 parental
animals. In addition, no test article-related macroscopic findings or
effects on organ weights were noted in the F1 or F2 pups at the
scheduled necropsies; no test article-related macroscopic findings were
noted for found dead F1 or F2 pups. No effects of the test article were
observed on the mean days of acquisition of balanopreputial separation
and vaginal patency in the F1 pups.
Decreased (not statistically significant) mean cumulative body weight
gains were noted in the 3000 mg/L group F0 males during study days 0-70
(pre-mating period) and study days 0-126 (entire generation). While
weekly mean body weight gain differences from the control group were
only statistically significant during study days 91-98, the reduced mean
cumulative body weight gains in the 3000 mg/L group males corresponded
to decreased water consumption and were considered test article-related.
Mean body weights were unaffected in the 3000 mg/L group males;
differences from the control group were slight and not statistically
significant.
A decreased (not statistically significant) mean cumulative body weight
gain was noted in the 3000 mg/L group F0 females during study days 0-70
(pre-mating period).
There were no clear trends in the weekly mean body weight gains for
these females; however, mean body weights were reduced in these females
from study days 56 through 70 (prior to mating; 5.1% to 6.3%) and after
the end of lactation on study day 126 (6.3%). Only the reduction on
study day 126 was statistically significant (p0.01). The decreased mean
body weights and cumulative body weight gain in this group corresponded
to decreased water consumption and were considered test article-related.
There were no effects on mean body weights or body weight gains in the
120, 360 and 1000 mg/L groups. Differences from the control group were
slight, did not occur in an exposure-related manner and/or were not
statistically significant.
Decreased mean water consumption was noted for the 3000 mg/L group F0
and F1 parental animals during the pre-mating period (females) or the
entire generation (males) and for the F1 pups gang-housed by litter from
PND 21-28. Water consumption was also often decreased in the 1000 mg/L
group males and females, although the decreases were less severe and the
onset was later than in the 3000 mg/L group. Mean water consumption in
the 1000 mg/L group was consistently reduced compared to the control
group beginning on study days 21-24; however, slight decreases were also
noted inconsistently earlier in the pre-mating period. The decreased
water consumption in the 1000 mg/L group continued through the first
week of gestation while the decreased water consumption in the 3000 mg/L
group females continued throughout gestation and lactation. The test
article-related decreases in water consumption were not considered an
adverse change due to the lack of associated effects on food intake and
food utilization.
Hormone Analysis:
No statistically significant test article-related changes in the mean
concentrations of T3, T4 or TSH were noted in the F0 or F1 parental
animals or in the F1 or F2 pups selected for analysis (PND 4 or PND 21).
The higher TSH values noted in the F0 males at the scheduled necropsy
were not considered test article-related in the absence of effects on T3
or T4, organ weights or adverse macroscopic or microscopic findings.
Test article-related decreased colloid within the thyroid glands of the
3000 mg/L F0 males was not considered adverse due to the lack of
associated functional effects.
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 233 mg/kg bw/day
- Species:
- rat
- Quality of whole database:
- The one study available is a Guideline and GLP two-generation reproduction study.
Effect on fertility: via dermal route
- Quality of whole database:
- Two rat studies are available; one (the key study) was conducted to GLP and OECD Guidelines, and the other is similar to a guideline study. The one rabbit study available was conducted according to the version of the OECD Guideline that was available at the time, with some variations. A further rabbit study is available that was conducted using a compound that is metabolised to resorcinol.
Additional information
In an OECD TG 416 study, Sprague Dawley rats (30/sex/group) were exposed to resorcinol via drinking water for at least 70 days prior to mating (WIL, 2005). Water concentrations were 0, 120, 360, 1000 and 3000 mg/L for the F0 and F1 generations. When expressed on a body weight basis (average F0 and F1 animals), the water concentrations corresponded to approximately: 0, 11, 31, 86 and 233 mg/kg/day for males over the entire generation; 0, 16, 48, 126 and 304 mg/kg/day for females during premating and gestation; and 0, 28, 85, 225 and 660 mg/kg/day for females during lactation, respectively. In offspring, these concentrations corresponded to approximately: 0, 11, 33, 93 and 245 mg/kg/day in males; and 0, 16, 41, 126 and 295 mg/kg/day in females. A peer review of the microscopic thyroid evaluation was conducted. (See Section 3.1.9 for specifics on the thyroid evaluation.) Reproductive parameters evaluated included gonadal function, estrous cyclicity, mating behavior, conception, gestation, parturition, lactation and weaning of the F0 and F1 generations and F1 and F2 neonatal survival, growth and development. Reproductive performance and spermatogenic endpoints were unaffected by resorcinol. No test article related effects were observed on F1 and F2 pup survival, macroscopic findings or effects on organ weights. Decreases in water consumption are indicated to be due to the poor palatability of the water containing the two highest concentrations of resorcinol. The NOAEL is considered to be 3000 mg/L for parental systemic and offspring toxicity (ca. 233 mg/kg/day (males), 304 mg/kg/day (females (premating and gestation)), and 660 mg/kg/day (females (lactation)) while the NOEL is 1000 mg resorcinol/L for decreases in water consumption (ca. 86 mg/kg/day (males), 126 mg/kg/day (females (premating and gestation)) and 225 mg/kg/day (females (lactation)). The NOAEL for reproductive toxicity (fertility and development) is 3000 mg/L which corresponds to 245 mg/kg bw (males) and 295 mg/kg bw (females) in the F1 generation.
Short description of key information:
Resorcinol was not a reproductive toxicant and did not cause reproductive effects in the rat when administered in drinking water.
Effects on developmental toxicity
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Principles of method if other than guideline:
- Study was designed to comply with OECD 414 dated Jan. 22, 2001.
- GLP compliance:
- yes
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Route of administration:
- oral: gavage
- Vehicle:
- other: purified water
- Duration of treatment / exposure:
- 6-19 days of gestation
- Frequency of treatment:
- Daily
- Duration of test:
- 20 days
- No. of animals per sex per dose:
- 24 per group
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- A total of 96 pregnant Sprague-Dawley female rats were allocated to four groups (24 per group). Three groups were administered with the test item,
Resorcinol (A011), by gavage once daily from day 6 to day 19 of gestation, inclusive, at the dose-level of 40, 80 or 250 mg/kg/day. One group of
females was only administered with the vehicle, purified water, at the same constant dose volume of 5 mL/kg; individual volumes were adjusted
according to the most recently recorded body weight. - Maternal examinations:
- The females were sacrificed on day 20 of gestation and subjected to a macroscopic examination.
- Fetal examinations:
- The numbers of corpora lutea, implantations and live fetuses were recorded. The fetuses were removed from the uterus, weighed, sexed and
externally examined. Half of the fetuses underwent soft tissue examination while the remaining fetuses received a skeletal examination. - Statistics:
- Statistical analysis: Mean values were compared by one-way analysis of variance and the Dunnett test (mean values being considered as normally
distributed and variances being considered as homogeneous). Percentage values were compared by the Fisher exact probability test. - Details on maternal toxic effects:
- Details on maternal toxic effects:
Maternal body weight and food consumption: At 250 mg/kg/day, the net body weight change was significantly lower (p>0.05%, -19%) than the
control group value. There were no other treatment effects on maternal body weight, body weight gain or food consumption.
Macroscopic post-mortem examination: No findings recorded at maternal necropsy were considered to be treatment-related.
Pregnancy data: All the group mean numbers of implantations and live fetuses and the extent of pre- and post-implantation losses were comparable with the controls. - Dose descriptor:
- NOAEL
- Effect level:
- 80 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
- Dose descriptor:
- NOAEL
- Effect level:
- 250 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
- Conclusions:
- The maternal No Observed Adverse Effect Level (NOAEL) of Resorcinol (A011) administered by oral route (gavage) to pregnant female rats was
considered to be 80 mg/kg/day based on statistically significant body weight changes and the developmental NOAEL was considered to be
250 mg/kg/day (highest dose tested).
Reference
Mortalities and clinical observations: No premature deaths occurred during the study and no clinical observations were considered to be treatment-related.
Fetal
data:
In the treated groups, the mean numbers of corpora lutea, implantation
sites, live fetuses, resorptions (early and late) were similar to the
control group values.
The mean male and female fetus weights were significantly greater at 250
mg/kg/day, when compared to the controls. This observation was
considered to be the consequence of the low control group values
(outside the range of the last version of Historical Control Data 3.8 g
- 4.5 g, and within the range of the control group values during the
period where this study was conducted: 3.6 g - 3.9 g), rather than, an
effect of the treatment. The probability to mask an effect in fetal body
weights resulting from the low control group value was evaluated but was
considered to be with a
very low probability according to the homogeneity of individual fetal
body weights, the absence of a dose-related trend in fetal body weights
or the good general ossification of the skeletons. The percentage of
male fetuses was similar to controls for all groups. As a result, it was
concluded
that there were no effects of treatment on fetal body weight.
Fetal abnormalities:
No external, soft tissue or skeletal malformations or variations were
considered to be treatment-related.
There was a significantly increase in the incidence of fetuses with an
incompletely ossified interparietal at 40 and 80 mg/kg/day, when
compared to controls (p0.05 and p0.01, respectively). The incidence of
incompletely ossified parietals was also significantly greater at 80
mg/kg/day, when compared to controls (p0.05). In the absence of any
effects at 250 mg/kg/day these observations were not considered to be
treatment-related.
There was a significantly greater incidence of incompletely ossified 5th
sternebra at 250 mg/kg/day, when compared to controls (p0.01). The
thoraco-lumbar region is known to be particularly labile in the rat and,
in the absence of other variations or malformations, this observation
was not
considered to be treatment-related.
No fetal malformations or variants were considered to be related to
treatment.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 250 mg/kg bw/day
- Species:
- rat
Additional information
In an OECD TG 414 study, female Sprague Dawley rats (24/group) were exposed to resorcinol via oral bolus dosing (gavage) from day 6 to day 19 of gestation at 0, 40, 80 or 250 mg/kg bw/day (CIT, 2004). At 250 mg/kg/day, the net body weight change was significantly lower (p>0.05%, -19%) than the control group value. There were no other treatment effects on maternal body weight, body weight gain or food consumption. No findings recorded at maternal necropsy were considered to be treatment-related. All the group mean numbers of implantations and live fetuses and the extent of pre- and post-implantation losses were comparable with the controls. In the treated group the mean number of corpora lutea, implantation sites, live fetuses and resorptions (early and late) were similar to control group values. In foetus, no external, soft tissue or skeletal malformations or variations were considered to be treatment related. The mean male and female fetus weights were significantly greater at 250 mg/kg bw/day when compared to the controls. However, this observation was considered to be the consequence of the low control group values that were outside the range when compared with historical control data. Further evaluations were conducted in which it was concluded that there were no effects of treatment on fetal body weights. There was a significant increase in the incidence of fetuses with an incompletely ossified interparietal at 40 and 80 mg/kg bw/day when compared to controls. The incidence of incompletely ossified parietals was also significantly greater at 80 mg/kg bw/day, when compared to controls. In the absence of any effects at 250 mg/kg bw/day these observations were not considered to be treatment-related. There was a significantly greater incidence of incompletely ossified 5thsternebra at 250 mg/kg bw/day when compared to the controls. The thoraco-lumbar region is known to be particularly labile in the rat and in the absence of other variations or malformations and, in the absence of other variations or malformations, this observation was not considered to be treatment-related. Resorcinol was not a developmental toxicant in this study. The maternal and development NOAELs are 80 and 250 mg/kg bw/day (highest dose tested), respectively. Teratogenicity was not detected.
Ten to thirteen Female Sprague Dawley rats were administered resorcinol by gavage at doses of 0, 125, 250 and 500 mg/kg bw/day during days 6 – 15 of gestation (DiNardo et al., 1985). Study methods were similar to standard guideline studies. Although a reduction of mean maternal weight gains occurred at days 0-6, 6-16 and 16-20, they were not statistically significant at the high doses. No additional significant differences were observed in the incidence of fetuses with gross, visceral or skeletal anomalies, the foetal weights and resorption rates are not modified or any of the other parameters investigated. Teratogenicity was not observed up to 500 mg/kg bw day. The maternal and developmental NOAEL is 500 mg/kg bw day (highest dose tested).
In a teratogenicity study, mated New Zealand white rabbits (18 -26 animals/dose) were administered resorcinol at doses of 0 (vehicle), 0 (positive control, vitamin A), 25, 50 or 100 mg/kg bw/day on days 6 -18 of gestation. Animals were kept until day 28 when they were necropsied and examined. No treatment related deaths or clinical or macroscopic effects occurred in any dose groups. Maternal bodyweight gain was reduced in the top dose group compared to controls. Pregnancy incidence and number of implantations were not affected by treatment with resorcinol. Post-implantation loss was slightly higher than controls in the bottom 2 dose groups. However, these losses were within historical controls and therefore are not considered to be an effect of treatment. The mean number of foetuses per doe and the sex distribution was comparable to controls. Litter and foetal weights were comparable for all dose groups. There were no foetal defects related to treatment with resorcinol. The positive control has slight effects on the foetal weight and teratogenic effects. A maternal NOAEL of 50 mg/kg bw/day can be derived for this study based on reduced bodyweight gain at the top dose. A developmental NOAEL of 100 mg/kg bw/day can be derived based on no observed effects on foetal development. The study was undertaken before the current version of the OECD 414 (2001) guidelines were available, however it is in-line with the previous version of the OECD 414 (1981). Lack of clear effects on maternal animals (only bodyweight gain was reduced in the top dose group) and reduced number of foetuses examined may have affected the sensitivity of the study. However, the results of this study are in-line with other studies on rabbit and rat species.
In a developmental toxicity study, resorcinol bis-diphenylphosphate (RDP; a compound for which resorcinol is known to be one of the major urinary metabolites) was administered to pregnant female New Zealand White rabbits (27/dose) at dose levels of 0, 50, 200 or 1000 mg/kg bw/day from days 6 through 28 of gestation. No biologically significant adverse effects were observed, and NOAELs of 1000 mg/kg bw/day (the highest dose tested) were identified for both maternal and developmental toxicity.
Justification for classification or non-classification
Based on the above studies, resorcinol was not a developmental toxicant and did not cause reproductive effects in the rat and rabbit when administered by gavage.
Additional information
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