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EC number: 203-585-2 | CAS number: 108-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study; Not GLP
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Reference Type:
- publication
- Title:
- The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits.
- Author:
- Flickinger, C.W.
- Year:
- 1 976
- Bibliographic source:
- American Industrial Hygiene Association Journal, 37:596-606.
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FHSLA
- Principles of method if other than guideline:
- The study was conducted in accordance with Federal Hazardous Substance Labeling Act (FHSLA), Federal Register Aug 12, 1961, p 7333-7341, Part 191 "Hazardous Substances Definitions and Procedural and Interpretative Regulations, Final Order".
- GLP compliance:
- no
Test material
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- resorcinol
- Details on test material:
- Flaked and Industrial Grade Resorcinol
Flaked Grade (deep, ivory colored solid) and Industrial Grade (dark brown-colored solid), no purity data available
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- Amount applied: 0.1 other: gm
- Duration of treatment / exposure:
- 72 hour(s)
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Six male albino rabbits were treated in determining the extent of injury that might be expected following accidental contamination of the eyes with each material. Two to four hours prior to the application of the material upon the cornea and into the conjunctival sac, the eyes were stained with fluorescein to assure the use of undamaged eyes. Since the material was water soluble, the standard test procedure was modified to test both the dissolved material and the semi-solid in its usual state. One tenth of a gram of the material was applied to one eye of each of six rabbits, the six untreated eyes serving as controls. The exposed eyes were not washed following application of the material. The eyes were examined and evaluated at 24 hours, 48 hours, and 72 hours after treatment for gross damage to the palpebral and bulbar conjunctivae, to the iris, and to the cornea. All damaged eyes were examined periodically thereafter for a maximum period of two weeks to evaluate the permanence of the damage and the rate and degree of repair.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 105
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- There was no significant difference in the response of the eyes of rabbits to Flaked or Industrial Resorcinol. Upon the application of 0.1 gm of either of the test materials into the eyes of male, albino rabbits, the conjunctivae became inflamed, the corneas opaque, and the rabbits gave evidence of marked discomfort. Examination at 24 hours post exposure showed severe conjunctivitis, iritis, corneal opacities occluding most of the iris, and corneal ulcerations. There was almost no perceptible improvement in the condition of the eyes during the observation period and by the 14th-day, all of the exposed eyes revealed kerataconus and pannus formation. The test substance, therefore, is an eye irritant as defined in the regulations pursuant to the FHSLA.
Using Draize methods, a numerical evaluation of the eye injuries at 24, 48 and 72 hours gave a resultant total eye irritation scores of 105, 105 and 105, respectively, with a maximum obtainable score of 110 for each time period. Classified as an eye irritant.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The author concluded the substance to be a severe eye irritant. The results were evaluated in association with EC 1272/2008 (CLP) and the substance was determined to be classified corrosive to the eye due to the lack of improvement in the condition of the eyes over the 14 day observation period.
- Executive summary:
Following the FHSLA protocol, six male albino rats were administered 0.1 gram of flaked and industrial grade resorcinol in a dissolved and semi-solid state into one eye with the other eye serving as the control (Flickinger, 1976; Koppers Company, 1962). At administration, the conjunctivae became inflamed, corneas were opaque and discomfort was observed. At 24 hours post exposure, observations included severe conjunctivitis, iritis, corneal opacities occluding most of the iris and corneal ulcerations. There was almost no perceptible improvement in the condition of the eyes during the observation period and by the 14thday, all of the exposed eyes revealed kerataconus and pannus formation. Total eye irritation scores following Draize method were 105/110 at 24, 48 and 72 hours. Resorcinol was concluded to be a severe eye irritant.
Following evaluation based on the criteria in EC 1272/2008 (CLP) the substance was determined to be classified corrosive to the eye due to the lack of improvement in the condition of the eyes over the 14 day observation period.
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