Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-585-2 | CAS number: 108-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline Study; Not GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Method: Federal Register of August 12 1961, pages 7333-7341.
The study was conducted in accordance with Federal Hazardous Substances Labeling Act (FHSLA), Federal Register Aug. 12, 1961, p 7333-7341, Part 191 "Hazardous Substances Definitions and Procedural and Interpretative Regulations, Final Order" - GLP compliance:
- no
Test material
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- resorcinol
- Details on test material:
- Industrial Grade Resorcinol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Vehicle:
- physiological saline
- Doses:
- 1000, 2000, 3980 and 7950 mg/kg
- No. of animals per sex per dose:
- 4/dose group, males
- Control animals:
- not specified
- Details on study design:
- Four groups of male albino rabbits were used (4/dose group), weighing between 2.3-3.0 kg after undergoing a seven day laboratory observation and acclimatization period.
The rabbits were administered the following doses of industrial resorcinol: 1000, 2000, 3980 and 7950 mg/kg. Prior to exposure, the animals were prepared by clipping the skin of the trunk, approximately 10% of the body surface, free of hair. One-half of each group was further prepared by making epidermal abrasions every two or three centimeters longitudinally over the area of future exposure. The abrasions were sufficiently deep to penetrate the stratum corneum but not to disturb the derma and cause bleeding. The skin and the material, which was evenly distributed on cotton gauze in an amount calculated to yield the desired dosage level, were moistened with physiological saline. The gauze and material were applied to the skin of the rabbits and the entire trunk was wrapped in an impervious plastic film. The maximum justifiable dosage level for solids in this procedure is approximately 4. 0 gm. /kg. which is twice the upper limit for the "toxic substance" category as defined in the regulations pursuant to the FHSLA. Following dosing, the rabbits were immobilized in stocks for 24 hours after which the dam and any excess chemical were removed and the skin was examined for gross changes. Mortality due to the effect of the chemical was considered complete after 14 days. All fatalities were subjected to autopsies to exclude extraneous causes of death while some survivors were sacrificed and examined for the existence of gross lesions. - Statistics:
- The skin penetration LD50, based upon mortality attributable to the material during the 14-day observation period, was estimated employing Thompson's method of moving averages using the tables of Weil.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 830 mg/kg bw
- Gross pathology:
- No internal gross lesions were observed at necropsy.
- Other findings:
- The material produced necrosis of the skin in all the rabbits exposed to 3980 mg/kg and above for the Flaked Grade and to 2000 mg/kg and above for the Industrial Grade. The rabbits exposed to 1000 mg/kg Flaked Grade showed only slight hyperkeratosis following signs of moderate to severe irritation after 24 hours contact. However the same dose of the Industrial Grade showed no signs of irritation seven days following contact.
Any other information on results incl. tables
RS-Freetext:
Industrial Grade:
Dosage mg/kg No. Died/No. Dosed Days after dosing on which death occurred
1000
0/4
-
2000
0/4
-
3980
4/4
1 (4)
7950
4/4
1 (4)
95% confidence limits: cannot be calculated due to the all
or none response.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 is 2830 mg/kg bw . The results were evaluated in association with the EC 1272/2008 (CLP). The substance does not fall within any categories identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.