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Diss Factsheets
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EC number: 203-439-8 | CAS number: 106-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No data on GLP but was a guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- no
- Remarks:
- Not specified in report
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
no data - Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Details on inoculum:
- Sludge was obtained from 10 locations (Fukogawa city sewage, Fukashiba industry sewage plant, Nakahama city sewage plant, Ochiai city sewage plant, Kitakami river, Shinano river, Yoshino river, Lake Biwa, Hiroshima bay and Dookai bay) four times each year. Inoculum is cultured in the laboratory on a glucose/peptone medium for 30-120 days prior to use in the test.
- Duration of test (contact time):
- 14 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Four test solutions were prepared: 1) water + test substance, 2) sludge + test substance, 3) sludge + aniline and 4) control blank.
- Preliminary study:
- no data
- Test performance:
- no data
- Parameter:
- % degradation (O2 consumption)
- Value:
- 18
- Sampling time:
- 14 d
- Details on results:
- no additional information available
- Results with reference substance:
- no additional information available
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- The biodegradability of epichlorohydrin was examined using the MITI test. Epichlorohydrin was not readily biodegradable in this test at a concentration (100 mg/l) where inhibition of the inoculum cannot be ruled out. No information on inhibitory effects of the test material on the inoculum is available.
- Executive summary:
The biodegradability of epichlorohydrin was examined using the MITI test. Epichlorohydrin was not readily biodegradable in this test.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: No data on GLP but was a guideline study.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- not specified
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
no data - Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Details on inoculum:
- Sludge was obtained from 10 locations (Fukogawa city sewage, Fukashiba industry sewage plant, Nakahama city sewage plant, Ochiai city sewage plant, Kitakami river, Shinano river, Yoshino river, Lake Biwa, Hiroshima bay and Dookai bay) four times each year. Inoculum is cultured in the laboratory on a glucose/peptone medium for 30-120 days prior to use in the test.
- Duration of test (contact time):
- 14 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Four test solutions were prepared: 1) water + test substance, 2) sludge + test substance, 3) sludge + aniline and 4) control blank.
- Preliminary study:
- no data
- Parameter:
- % degradation (O2 consumption)
- Value:
- 68
- Sampling time:
- 14 d
- Parameter:
- % degradation (TOC removal)
- Value:
- 84.3
- Sampling time:
- 14 d
- Remarks on result:
- other: Test terminated after 14 d.
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 92.5
- Sampling time:
- 14 d
- Remarks on result:
- other: Test terminated after 14 d.
- Details on results:
- no additional information provided
- Results with reference substance:
- Result for references substance not given in the MITI database. For the study results to be accepted, the percentage biodegradation of aniline has to be >40 and >60% in 7 and 14 days, respectively.
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test material, 3 -chloro-1,2 -propylene glycol, meets the definition of readily biodegradable in the OECD 301C test.
- Executive summary:
The test material, 3 -chloro-1,2 -propylene glycol, which is the initial degradation product of epichlorohydrin, meets the definition of readily biodegradable in the OECD 301C test.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted in accordance to any guidelines and is a non GLP study.
- Principles of method if other than guideline:
- Ready biodegradability study using non-acclimated organisms over an observation period of 20 days and comparison of BOD and ThOD as parameter.
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Remarks:
- no additional information specified
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- no data
- Duration of test (contact time):
- 20 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 48
- Sampling time:
- 20 d
- Remarks on result:
- other: After 5, 10 and 15 days, 4, 33 and 36%, respectively, of the theoretical oxygen consumption was used.
- Details on results:
- Theoretical oxygen consumption was 1.21
- Conclusions:
- Using non-adapted organisms, 48% of the epichlorohydrin was biodegraded in 20 days based on BOD/ThOD.
- Executive summary:
Using non-adapted organisms, 48% of the epichlorohydrin was biodegraded in 20 days based on BOD/ThOD.
Referenceopen allclose all
Epichlorohydrin was not readily biodegradable in this test.
The test material, 3 -chloro-1,2 -propylene glycol, meets the definition of readily biodegradable in the OECD 301C test.
Using unadapted mirco-organisms, 48% of the epichlorohydrin was biodegraded in 20 days.
Description of key information
The hydrolysis product of Epichlorohydrin is readily biodegradable. The Japanese Institute of Technology and Evaluation concludes Epichlorohydrin to be readily biodegradable based on this result.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Biodegradability of Epichlorohydrin has been investigated following the OECD 301 C (MITI) protocol at 100 mg/l; a concentration that may be inhibitory to the inoculum (no information on inhibition available). However, the hydrolysis product of Epichlorohydrin is readily biodegradable. The Japanese Institute of Technology and Evaluation concludes Epichlorohydrin to be readily biodegradable based on this result.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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