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Diss Factsheets
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EC number: 200-843-6 | CAS number: 75-15-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to other aquatic organisms
Administrative data
- Endpoint:
- toxicity to other aquatic vertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicity and teratogenic effects of Carbon disulphide in frog embryo
- Author:
- Ghate HV
- Year:
- 1 985
- Bibliographic source:
- Rivista di Biologia Vol. 78
- Reference Type:
- secondary source
- Title:
- Carbon disulfide
- Author:
- GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
- Year:
- 1 991
- Bibliographic source:
- BUA report 83
Materials and methods
- Principles of method if other than guideline:
- Effects of different concentrations of carbon disulphide on the embryonic development of frog investigated.
- GLP compliance:
- no
Test material
- Reference substance name:
- Carbon disulphide
- EC Number:
- 200-843-6
- EC Name:
- Carbon disulphide
- Cas Number:
- 75-15-0
- Molecular formula:
- CS2
- IUPAC Name:
- methanedithione
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- CS2 was dissolved in alcohol (1 mL CS2 in 50 mL alcohol). This solution was used to prepare various concentrations of CS2 in aged tap water. Controls received appropiate quantity of alcohol.
Test organisms
- Test organisms (species):
- Microhyla ornata
- Details on test organisms:
- Fresh, naturally fertilized eggs of the frog Microhyla ornata were obtained from a local, unpolluted pond. The jelly was removed with forceps and the eggs were transferred to aged tapwater. Eggs in early gastrulation (dorsal lip) were then used in experimentation as per the procedure described earlier (Ghate, 1980 & 1983 a). 50 Embryos per concentration expodes.
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
Results and discussion
- Details on results:
- The embryonic development of frogs was disturbed at a concentration of 126 mg CS2/L, with no hatching taking place (100% mortality) .
Any other information on results incl. tables
4 µL CS2 / 100 mL aged tapwater: no mortality / Development normal
8 µL CS2 / 100 mL aged tapwater: no mortality / Hatching delayed by few hours / Tadpoles showed slightly abnormal notochord
12 µL CS2 / 100 mL aged tapwater: no mortality / Hatching delayed 50% failed to hatch even at 96 hrs. / All were oedematic with wavy notochord
16 µL CS2 / 100 mL aged tapwater: 90% mortality in 24 hrs. / All dead in 48 hrs.
20 µL CS2 / 100 mL aged tapwater: 100% mortality in 24 hrs.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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