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EC number: 800-940-9 | CAS number: 35836-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 September 2012 - 28 September 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The determination of the water solubility was performed using the OECD 105 guideline (elution column). This study was considered as reliable with restrictions because not enough details on quantification of the substance were reported in the report.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (27 July 1995)
- Deviations:
- no
- Principles of method if other than guideline:
- This method is based on the elution of a test substance with water from a micro-column which is charged with an inert support material (celite), previously coated with an excess of the test substance. The water solubility is given by the mass concentration of the eluate when this has reached a plateau as a function of time. A second experiment is performed at half the flow rate of the first. If the results of the two runs are in agreement, the test is satisfactory. If the measured solubility is higher with the lower flow rate, then the halving of the flow rate must continue until two successive runs give the same solubility.
- GLP compliance:
- not specified
- Type of method:
- column elution method
- Key result
- Water solubility:
- ca. 15 mg/L
- Temp.:
- 20 °C
- pH:
- >= 5 - <= 7.5
- Remarks on result:
- other: Measured pH : pH=5 at the beginning of the both experiment and pH=7.5 at the end of the both experiment. The relative difference between the results of the two experiments is 6.96%, less than 30% as required by the OECD 105 - elution column method.
- Details on results:
- Mean of two solubility values obtained in two different experiments.
Concentrations observed at 25 mL/h: mean of the five last samples = 15.62 mg/L (RSD = 4.15% : less than 30% as required by the OECD 105 - elution column method)
Concentrations observed at 12.5 mL/h: mean of the five last samples = 14.57 mg/L (RSD = 3.17 % : less than 30% as required by the OECD 105 - elution column method) - Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
Two determinations were conducted according to the column elution method (OECD Guideline No 105).
The mean of the two water solubility values obtained in the two different experiments is: (15.62 + 14.57) / 2 = 15.10 mg/L
The relative difference between the results of the two experiments is: (15.62 – 14.57) / 15.10 = 6.96 %
The mean values obtained from two experiments did not differ by more than 30%, so these results are valid. - Executive summary:
The determination of the water solubility of nopyl acetate was performed using the column elution method (OECD Guideline No 105).
Due to the physicochemical properties of the test item (stability, volatility, adsorption on glass), the samples were analyzed as soon as possible after sampling. This precaution is crucial in order to avoid underestimation and variations of the measured concentrations.
Two independent experiments were carried out. The concentration of the substance was regularly measured by HPLC-UV (High Performance Liquid Chromatography with UV detector). The water solubility of nopyl acetate was recorded when the concentration reached a plateau.
The water solubility of nopyl acetate was 15.10 mg/L. This value is the mean of two independent measurements.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 September 2012 - 28 September 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The determination of water solubility was performed using the slow stirring method adapted from OECD 123 guideline. This study was considered as reliable with restrictions because not enough details on quantification of the substance were reported in the report.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- other: adapted from OECD Guideline 123
- Deviations:
- no
- Principles of method if other than guideline:
- In a stirring vessel maintained at 20°C, ultra-pure water covered by a thin layer of the test item is slow stirred. The aim of this method is to prevent the formation of emulsions when saturating water. That can occur with the shake flask method and lead to a solubility overestimation. The water solubility is given by the mass concentration in water when this has reached a plateau as a function of time. A second experiment is performed in the same conditions.
- GLP compliance:
- not specified
- Type of method:
- other: slow-stirring method
- Key result
- Water solubility:
- ca. 23 mg/L
- Temp.:
- 20 °C
- pH:
- 5
- Remarks on result:
- other: Mean of two solubility values obtained in two different experiments.
- Details on results:
- First experiment : mean of the five last samples = 23.35 mg/L (RSD = 2.90% : less than 15% as required by the OECD 105 - flask method)
Second experiment : mean of the five last samples = 22.76 mg/L (RSD = 2.48% : less than 15% as required by the OECD 105 - flask method) - Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
Two determinations were conducted according to the slow stirring method (adapted form OECD Guideline No 123).
The mean of the two water solubility values obtained in the two different experiments is: (2,76 + 23,35) / 2 = 23.06 mg/L
The relative difference between the results of the two experiments is: (23,35 – 22,76) / 23,06 = 2.56 % - Executive summary:
The determination of the water solubility of nopyl acetate was performed using the slow stirring method adapted from OECD Guideline No 123.
Due to the physicochemical properties of the test item (stability, volatility, adsorption on glass), the samples were analyzed as soon as possible after sampling. This precaution is crucial in order to avoid underestimation and variations of the measured concentrations.
Two independent experiments were carried out. The concentration of the substance was regularly measured by HPLC-UV (High Performance Liquid Chromatography with UV detector). The water solubility of the test item was recorded when the concentration reached a plateau.
The water solubility of nopyl acetate was 23.06 mg/L. This value is the mean of two independent measurements.
Referenceopen allclose all
Preliminary test
The approximate solubility determined by the preliminary test was lower than 100 mg/L.
First experiment at a flow rate of 25 mL/h
The concentrations obtained as a function of time during this first experiment at 25 mL/h are presented in graph 1 : "Concentrations observed at 25 mL/h"
Measured pH :
- at the beginning of the experiment : 5
- at the end of the experiment : 7.5
The mean ± standard deviation of the five last samples is 15.62 ± 0.65 mg/L (RSD = 4.15% : less than 30% as required by the OECD 105 - elution column method)
The maximum difference observed in the five last samples is
16,28 - 14.63 = 1.65 mg/L
The mean of these two maximum values is
(16.28 + 14.63) / 2 = 15.46 mg/L
The relative difference, corresponding to the ratio of the maximum difference and the mean of the two maximum values is
1.65 / 15.46 = 10.67 %
The five last sample concentrations do not differ by more than ± 30%, which means that equilibrium was established.
Second experiment at a flow rate of 12.5 mL/h
The concentrations obtained as a function of time during this second experiment are presented in graph 2 : "Concentrations observed at 12.5 mL/h".
Measured pH :
- at the beginning of the experiment : 5
- at the end of the experiment : 7.5
The mean ± standard deviation of the five last samples is 14.57 ± 0.46 mg/L (RSD = 3.17 % : less than 30% as required by the OECD 105 - elution column method)
The maximum difference observed in the five last samples is
15.25 – 14.01 = 1.24 mg/L
The mean of these two maximum values is
(15.25 + 14.01) / 2 = 14.63 mg/L
The relative difference, corresponding to the ratio of the maximum difference and the mean of the two maximum values is
1.24 / 14.63 = 8.48 %
The five last sample concentrations do not differ by more than ± 30%, which means that equilibrium was established.
Preliminary test
The approximate solubility determined by the preliminary test was lower than 100 mg/L.
First experiment
The concentrations obtained as a function of time during this first experiment are presented in graph 1 : "Concentrations observed- first experiment"
Measured pH :
- at the beginning of the experiment : 5
- at the end of the experiment : 5
The mean ± standard deviation of the five last samples is 23.35 ± 0.68 mg/L (RSD = 2.90% : less than 15% as required by the OECD 105 - flask method)
The maximum difference observed in the five last samples is
24.53 - 22.83 = 1.70 mg/L
The mean of these two maximum values is
(24.53 + 22.83) / 2 = 23.68 mg/L
The relative difference, corresponding to the ratio of the maximum difference and the mean of the two maximum values is
1.70 / 23.68 = 7.18 %
Second experiment
The concentrations obtained as a function of time during this second experiment are presented in graph 2 : "Concentrations observed- second experiment".
Measured pH :
- at the beginning of the experiment : 5
- at the end of the experiment : 5
The mean ± standard deviation of the five last samples is 22.76 ± 0.56 mg/L (RSD = 2.48% : less than 15% as required by the OECD 105 - flask method)
The maximum difference observed in the five last samples is
23.22 – 21.89 = 1.33 mg/L
The mean of these two maximum values is
(23.22 + 21.89) / 2 = 22.56 mg/L
The relative difference, corresponding to the ratio of the maximum difference and the mean of the two maximum values is
1.33 / 22.56 = 5.90 %
Description of key information
The water solubility was determined by two methods: the column elution method and the slow-stirring method.
A mean value was calculated to give a representative estimation of the water solubility of the substance.
The water solubility of nopyl acetate is 19.08 mg/L at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 19.08 mg/L
- at the temperature of:
- 20 °C
Additional information
Two key studies were conducted: the first one according to OECD 105 Guideline (column elution method) and the second one adapted from OECD 123 Guideline (slow-stirring method).
The results are scientifically acceptable but not obtained under GLP (reliable with restrictions). The arithmetical mean value of the results of these 2 experiments can be retained as key value for chemical safety assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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