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EC number: 215-553-5 | CAS number: 1330-86-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (14d) = 865 mg/kg soil dw for Eisenia fetida (read across to Bis(ethylhexyl) adipate CAS 103-23-1)
Key value for chemical safety assessment
Additional information
No data are available for the acute or chronic toxicity to earthworm for Diisooctyl adipate (CAS 1330-86-5). Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category member Bis(2-ethylhexyl)adipate (DEHA, CAS 103-23-1) was conducted. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used. In this study earthworms were exposed to DEHA amended quartz sand and soil (method 88 / 302 EWG). LC50s of >1000 mg/kg and 865 mg/kg were reported after 7 and 14 day exposures, respectively (Huels, 1996). Due to the structural and property similarities with the tested category member Bis(2-ethylhexyl)adipate (CAS 103-23-1) this result is also applicable to read across to Diisooctyl adipate (CAS 1330-86-5). Further, studies on the short term toxicity to earthworm, available for the category PFAE linear, support the assumption of expected negligible effects to terrestrial organisms with LC50 values for earthworm well above 100 mg/kg soil dw (i.e. LC50 (14d) > 1000 mg/kg for Dibutyl adipate CAS 105-99-7 and Bis(tridecyl) adipate CAS 16958-92-2, respectively).
According to ECHAs Guidance R.7c, the absence of chronic or long-term effects in aquatic organisms up to the substance solubility limit, can be used as part of a Weight of Evidence argument to modify/waive the data requirements of Annex IX and X. For the category PFAE linear, there are three chronic tests on aquatic invertebrates available for insoluble category members (i.e. CAS 103-23-1 Bis(ethylhexyl)adipate; CAS 33703-08-1 Diisononyl adipate and CAS 103-24-2 Bis(2-ethylhexyl) azelate). These substances exhibit log Kow values > 5 and a water solubility < 0.05 mg/L. In none of these tests effects on Daphnia were observed in nominal concentrations well above the limit of water solubility. Therefore, it is assumed that chronic tests on terrestrial organisms will not result in a different outcome and no chronic tests for terrestrial organisms are either provided, or deemed as necessary for the chemical safety assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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