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EC number: 438-930-8 | CAS number: 2550-52-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 to 25 August 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.13 mg/L
- Temp.:
- 20 °C
- pH:
- >= 7.4 - <= 7.5
- Conclusions:
- A water solubility value of 0.13 mg/L (at 20 °C, pH 7.4 - 7.5) was determined for the test substance according to OECD guideline 105.
Reference
Results and Discussion
For the higher flow rate of 0.69 mL/min, the equilibrium concentration was achieved after 49 hours with seven consecutive samplings showing a relative standard deviation of 5.4% and a deviation between highest and lowest measured concentration of 13.4%. For the lower flow rate of 0.35 mL/min, the equilibrium concentration was achieved after 28 hours with five consecutive samplings showing a relative standard deviation of 13.5% and a deviation between highest and lowest measured concentration of 26.5%. Detailed results are reported in the table below.
Results for Determination of Water Solubility
Experiment Number |
Flow Rate |
Sample Number |
pH (a) |
Sampling Time |
Measured Concentration of Test Item in Sample x |
Water Solubility
Mean Value ± Std. Dev. |
Rel. Std. Dev. |
|
[mL/h] |
|
|
[hours] |
[mg/L] |
[mg/L] |
[%] |
1 |
0.69 |
16 |
6-7 |
49 |
0.132 |
0.143 ± 0.008 |
5.4 |
17 |
6-7 |
50 |
0.136 |
||||
18 |
6-7 |
51 |
0.149 |
||||
19 |
6-7 |
52 |
0.151 |
||||
20 |
6-7 |
53 |
0.152 |
||||
21 |
6-7 |
54 |
0.141 |
||||
22 |
6-7 |
55 |
0.143 |
||||
2 |
0.35 |
9 |
6-7 |
28 |
0.115 |
0.114 ± 0.015 |
13.5 |
10 |
6-7 |
30 |
0.105 |
||||
11 |
6-7 |
32 |
0.103 |
||||
12 |
6-7 |
34 |
0.141 |
||||
13 |
6-7 |
36 |
0.108 |
||||
Overall Mean: |
0.13 |
|
Remark:
The Table only shows the data obtained during the equilibrium phase (RSD of five samples < 30 %).
(a) The pH value in the individual samples was measured with special indicator strips. After the end of the experiment the pH of the bulk solution was measured using an electrode: the values were 7.4 for experiment 1 and 7.5 for experiment 2.
The deviation between the mean values obtained for the two different flow rates was 20.2 %.
According to the test guideline five consecutive samples should not differ in concentration by more than 30% and the mean values obtained from two tests with different flows should not differ by more than 30%. These criteria were fulfilled and therefore, the study is valid.
The R² fit of the calibration curve used was 0.99. This reflects the linearity of the analytical system within the calibration range of 0.0316 - 0.264 mg test item /L.
The calibration was verified by a 2nd weighing of the test item and dilution of this stock solution into the calibration curve at levels of 0.0489, 0.0974 and 0.193mg/L. Analysis of these solutions and evaluation against the calibration curve yielded recoveries of 90 %, 113 % and 109 % compared to the nominal values. These data show the correct preparation of the calibration solutions.
The stability of the analytical system during the measurement series was confirmed by repeated injection of the calibration solutions.
An analysed analytical blank (solvent mixture) did not affect the chromatogram at the retention time of the test item.
Description of key information
Water solubility: 0.13 mg/L at 20 °C, pH 7.4 -7.5 (OECD 105, column elution method)
Key value for chemical safety assessment
- Water solubility:
- 0.13 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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