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EC number: 237-732-7 | CAS number: 13952-84-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No studies are available for sec-Butyllamine, however 3 studies was performed with the analogue monoisopropylamine and used for read across to sec-Butylamine (see justification for read across document section 7.5.2 , 7.8.1 and 7.8.2). The purpose of these studies was to examine the toxicity of inhaled isopropylamine (MIPA) in Sprague-Dawley rats and their offspring.
This project consisted of three studies: a male fertility study, a female reproduction study, and a subchronic toxicity study.
Animals in these three studies were exposed concurrently.
In the fertility and reproduction studies performed according to OECD 415, four groups of 20 male and 25 female rats each were exposed for 6 hrs/day, 5 days/wk
(except holidays) for approximately 10.5 weeks. Each exposed male was then consecutively cohoused (1:1) with two unexposed females;
exposed females were cohoused (1:1) with unexposed males. Treated males and females were exposed during the mating period
(5 days/wk). Once mating occurred, treated females were exposed 7 days/wk through gestation day 20. Untreated female mates
of exposed males were terminated approximately two weeks after copulation to assess fertility. Exposed females were housed in delivery boxes and delivered their pups. Pups were weaned on lactation Day 21 and necropsied. Mean analytical exposure concentrations were 20, 100, and 499 mg IPA per cubic meter. The mean body weight of exposed high level males was significantly reduced throughout most of the study. There were no treatment-related effects on mating, fertility,or reproduction parameters in exposed males or females. No gross or microscopic pathology changes were noted in FO or F1 animals.
The following information is taken into account for any hazard / risk assessment:
NOAEC = 500 mg/m3: No adverse effect on reproductive performance in the P-generation and no adverse effects on development of the progeny of the P-generation (F1)
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 499 mg/m³
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Reliability 1
Effects on developmental toxicity
Description of key information
No developmental study is performed with sec-Butylamine. However read across approach was applied with a study conducted in a manner equivalent or similar to OECD Guideline 414 (Prenatal Developmental Toxicity Study) with the analogue isopropylamine (see section 7.8.2). Groups of 25 female Sprague-Dawley rats were exposed by whole body vapor inhalation to isopropylamine at 50, 500 or 1000 mg/m3on gestation days 6-15 (Kier and Thake, 1988). Embryonal and fetal development was not impaired following inhalation exposure of pregnant rats to high levels of isopropylamine. Maternal toxicity was observed at 1000 mg/m3, based on effects on bodyweight, treatment-related clinical signs (nasal discharge, rales, labored breathing, sneezing and fur staining/encrustation) and macroscopically observed reduced abdominal fat. The NOAEC (maternal) was 500 mg/m3, and the NOAEC (offspring) was 1000 mg/m3.
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEC
- 500 mg/m³
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Reliability 1
Justification for classification or non-classification
Classification is not warranted.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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