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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 272-695-0 | CAS number: 68909-18-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study planned
- Study period:
- Sub-chronic oral toxicity with reproductive toxicty screen
- Justification for type of information:
- With reference to ECHA decision CCH-D-2114453719-37-01/F, data requests were made for Annex IX end points but in view of tonnage limit not being reached in this period, the testing is being down-graded to OECD 422 screening studies. There is no planned increase in tonnage to trigger future Annex IX requirements.
Attemnpts were previously made to adapt the endpoint to avoid animal testing based on corrosivity and citing animal welfare reasons, but this was rejected by ECHA
Data has not been found on similar substances and it is considered grouping or read-across is possible
Biological and abiotic degradation studies have been performed, but preliminarty results available at the time of this proposal suggest stability of th esubstance and no significant formation or transormation products or metabolites. The start of this work needs to be delayed until confirmation is received from the laboratory that evaluation of transformation products or metabolites will be possible to avoid animal testing. This confirmation is expected early 2021 (testing delayed in 2020 due to Covid restrictions).
• Available GLP studies - none
• Available non-GLP studies - none
• Grouping and read-across - previous request not accepted by ECHA
• Historical human data - no indication of human health concerns
• (Q)SAR - not possible for the UVCB
• In vitro methods - no validated method available
• Weight of evidence - previous request not accepted by ECHA, based on type of substance
• Substance-tailored exposure driven testing - previous request not accepted by ECHA, based on corrosive properties and use only under controlled industrial conditions.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Pyridinium, 1-(phenylmethyl)-,ethyl methyl derivs., chlorides
- IUPAC Name:
- Pyridinium, 1-(phenylmethyl)-,ethyl methyl derivs., chlorides
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Details on route of administration:
- Note for animal welfare purposes, the test material will be administered in a buffered test mediaum to mitigate effect of pH
- Analytical verification of doses or concentrations:
- yes
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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