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EC number: 500-209-1 | CAS number: 68412-54-4 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
In vitro studies
Study design |
Critical effect |
Reference |
NPE-2 Estrogen dependent cell proliferation assay Estrogen sensitive human breast tumor MCF-7 and ZR-75 cells cultured in presence of fetal calf serum stripped of hormones. Estrogens overcome this inhibition and the proliferative effect measured. NPE-2 concentrations ranged from 0.1 nM to 10 µM. |
NPE-2 at concentrations of ≤ 100 nM produced no estrogenic activity. NPE-2 at 1 and 10 μM produced proliferative response which at the higher concentration was similar to that produced by estradiol. 17β-estradiol was 1000 times more potent. |
White R et al. (1994)
|
NPE-2 Transcriptional activity of ER directly MCF-7 and chicken embryo fibroblasts (CEF) cells transfected with reporter gene pEREBLCAT and a mouse estrogen receptor. |
NPE-2 stimulated transcription at culture concentrations of 1 and |
White R et al. (1994)
|
In vivo studies
Study design |
Critical effect |
Reference |
NPE-4 Female rats; oral exposure; up to 1000 mg/kg bw/d; 3 or 4 days; |
Lack of uterine growth |
Bakke D (2003) |
NPE-9 Sperm study Male mice; IP doses of 20, 40, 50, 60 mg/kg bw/d; 5 days |
NOAEL > 60 mg/kg bw/d. No increase in frequency of morphologically abnormal sperm. |
Buttar HS et al. (1986) |
NPE-9 Female rats; oral exposure; up to 1000 mg/kg bw/d; 3 or 4 days |
Lack of uterine growth |
Bakke D (2003) |
NPE-9 Humans- intravaginal application; mg/kg bw/d) |
No effects on blood chemistries or on hepatic function. |
Malyk B (1981, 1984) |
NP and NPEs are frequently discussed as endocrine disrupters. Due to pending disagreements with or interpretation of the definition of an endocrine disrupter, this view is, however, contentious. While NP and shorter chain NPEs undoubtedly show endocrine activity (particularly estrogenicity) in various in vitro and in vivo screening assays, this did for example not manifest itself in endocrine toxicity in Level 5in vivoassays for NP. The EU risk assessment report stated that the estrogenic activity of NP and NPEs with ethoxylation degrees ≤ 3 is approximately 3-6 orders of magnitude less than that of estradiol (EU RAR, 2002). Beyond an ethoxylation degree of 4 and with increasing degree of ethoxylation, the estrogenicity of nonylphenol ethoxylates disappears. In the absence of evidence of specific endocrine-mediated toxicity and the low level of estrogenicity of nonyl phenol ethoxylates, DNELs established based on chronic toxicity data for NPE are considered protective for the NPEO uses considered in this CSR for workers, professional users and consumers.
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