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Diss Factsheets
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EC number: 201-557-4 | CAS number: 84-74-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1984
Materials and methods
- Principles of method if other than guideline:
- No guideline specified, cf. "Any other information on material and methods" for details.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dibutyl phthalate
- EC Number:
- 201-557-4
- EC Name:
- Dibutyl phthalate
- Cas Number:
- 84-74-2
- Molecular formula:
- C16H22O4
- IUPAC Name:
- dibutyl phthalate
1
- Specific details on test material used for the study:
- The source and general characteristics of the used organic chemicals were at least 98% purity. Chemicals were purchased from Aldrich Chem. Co., Milwaukee, WI, Eastman Kodak Co., Rochester, NY, and Fisher Scientific Co., Fairlawn, NJ.
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- The worm were grown in the laboratory at room temperature (20-22° C) on a consistent organic food source, horse (equus caballus) manure. Care was taken, that manure from medicated animals was not used.
Study design
- Study type:
- laboratory study
- Substrate type:
- other: filter paper (contact test), artificial soil (artificial soil test)
Test conditions
- Test temperature:
- 20° C
- pH:
- 6.0 +/- 0.5 (artificial soil test)
- Moisture:
- 35% (artificial soil test)
- Reference substance (positive control):
- yes
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 050 - 1 750 other: µg/cm²
- Basis for effect:
- mortality
- Remarks:
- contact test
Any other information on results incl. tables
Table 1 lists the indiviuals LC50 values and 95% confidence intervals for the 44 chemicals tested in the contact tests, their slubility and vapor pressure. Table 2 lists the combined values lists the combined values for 6 groups of chemicals evaluated in the contact tests, in the order of the most toxic group (phenols) to the least toxic group (phthalates).
Table 3 identifies the 10 most toxic and the 10 least toxic organic chemicals as determined by the contact tests. The 10 least toxic chemicals included five phthalates.
The phthalates, the least toxic chemical group tested, are very low in solubility and vapor pressure. A brief comparison of the tested chemicals suggests that compounds, that have the least toxicity to earthworms, are those that are not very soluble in water or have a high water pressure.
The lower the molecular weight of the phthalate compound, the greater toxicity in the contact tests (Table 1). Toxicity could be related to solubility, since the more soluble phthalates were the more toxic chemicals.
In the artificial soil tests the phthalates were one of the least toxic chemicals tested.
Applicant's summary and conclusion
- Conclusions:
- A mean LC50 of 1360 µg/cm² was established.
- Executive summary:
Two test methods, the 2d contact test and the 14d artificial soil test, were used to evaluate the impact of six major classes of organic chemicals on the earthworm (eisenia fetida). Of the organic chemicals tested phenols and amines were the most toxic to the worm, followed in descending order of toxicity by the substituted aromatics, halogenated aluphaties, polycyclic aromatic hydrocarbons and phthalates.
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