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Registration Dossier
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Diss Factsheets
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EC number: 201-557-4 | CAS number: 84-74-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: methods are not documented, also lacking testing guidelines
- Radiolabelling:
- yes
- Test organisms (species):
- other: Daphnia magna, Gammarus pseudolimnaeus, Chironomus plumosus, Hexagenia bilineata
- Route of exposure:
- aqueous
- Test type:
- static
- Total exposure / uptake duration:
- 7 - 14 d
- Conclusions:
- The low degree of toxicity and the high excretion rate of di-n-butyl and di-2-ethylhexyl phthalates might suggest that these compounds would be relatively safe as far as aquatic organisms are concerned. However, the present data indicate that these compounds can be detrimental to the reproduction of aquatic organisms at low chronic concentrations.
- Executive summary:
This is part of a study with DBP and di-2-ethylhexyl phthalate relating to acute toxicity, reproduction and accumulation & excretion. Only the last examinations (accumulation & excretion) concerning DBP are documented here.
Reference
All invertebrates continuously exposed to 14C-di-n-butyl phthalate showed an initial rapid uptake and accumulation of radioactive residues several hundred times greater than the concentration in water (Table 2). With the exception of some species of invertebrates, the accumulation of di-2-ethylhexyl phthalate was greater than that of di-n-butyl phthalate. Di-2-ethylhexyl phthalate residues were
accumulated and stored by scuds during a 14-day exposure at levels 3600 times greater than the 0.1 ,g/l. concentrations in the surrounding water, whereas scuds exposed for 14 days to 0.1 pg/l. of di-n-butyl phthalate accumulated total body concentrations 1400 times the phthalate concentrations in water. Phthalic acid esters were accumulated in invertebrates to a similar degree as that found with the same species of invertebrates exposed to organochlorine insecticides.
Waterfleas (Daphnia magna) were exposed to 0.1 mg/l. of di-n-butyl phthalate for 7 days and then transferred to fresh flowing
water to determine the time required for elimination of phthalate residues. After 3 days, 50% of the total radioactivity remained;
25% of the activity was still present after 7 days in fresh water. Invertebrate metabolism of phthalic acid esters was not determined, and the loss in radioactive residues may have been due to metabolism and/or excretion of the parent compound.
Description of key information
Key value for chemical safety assessment
Additional information
Based on a log Pow of 4.11 (Leyder & Boulanger 1983) a bioconcentration factor of 780 was calculated (Bysshe 1982).
In 1974 the Environmental Agency Japan conducted studies with DIBP on fish and with water. Water samples showed DIBP levels of 0.16 to 1.2 micrograms per litre. Fish samples showed 150 to 470 micrograms per kilogram. Neither the species nor the applied concentration of DIBP is mentioned. According to the stated values bioaccumulation factors of 125 to 2937 were determined. (Environmental Agency Japan 1985)
Source: Beratergremium für umweltrelevante Altstoffe (BUA) der Gesellschaft deutscher Chemiker: Diisobutylphthalat, BUA-Stoffbericht 201; Dr . H. Behret, Gesellschaft deutscher Chemiker, Postfach 900440, 60444 Frankfurt am Main, Germany; p. 50; ISBN 3-7776-0788-6; S. Hirzel Verlag, Stuttgart 1997
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