Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-039-0 | CAS number: 91-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is fromauthorized database
Data source
Reference
- Reference Type:
- other: authorized database
- Title:
- Single Dose Oral Toxicity Test of Tolylene diisocyanate in Rats
- Author:
- J-CHECK
- Year:
- 2 012
- Bibliographic source:
- Ministry of Health, Labour and Welfare", "Ministry of the Environment" and "National Institute of Technology and Evaluation, J-CHECK 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The single dose toxicity test of 2, 6Toluene diisocyanate in male and female Crj: CD (SD) rats by oral (gavage) administration.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- m-tolylidene diisocyanate
- EC Number:
- 247-722-4
- EC Name:
- m-tolylidene diisocyanate
- Cas Number:
- 26471-62-5
- IUPAC Name:
- 2,4-diisocyanato-1-methylbenzene
- Reference substance name:
- Toluene diisocyanate
- IUPAC Name:
- Toluene diisocyanate
- Details on test material:
- - Name of test material (as cited in study report): Toluene diisocyanate
- Molecular formula (if other than submission substance): C9H6N2O2
- Molecular weight (if other than submission substance): 174.16 g/mole
- Substance type: Organic
- Physical state: Colorless to yellow liquid ... turns pale yellow on exposure to air
Purity >99%
Remarks The test substance Toluene diisocyanate was a mixture of 2,4Toluene diisocyanate and 2,6Toluene diisocyanate .It is present in a ratio of 80:20 i.e. 2,4Toluene diisocyanate: 2,6Toluene diisocyanate. Our target substance was present in a ratio of 20.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: No data available.
- Age at study initiation: No data available.
- Weight at study initiation: male153-171 g and female-128-144 g
- Fasting period before study:
- Housing: No data available.
- Diet (e.g. ad libitum): No data available.
- Water (e.g. ad libitum): No data available.
- Acclimation period: No data available.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 -26°C
- Humidity (%):50-63 %
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12 hours light, 12 hours dark ( 150-300 lux)
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- No data available
- Doses:
- 0 and 2000 mg/kg
- No. of animals per sex per dose:
- Total no. of animals-20
0 mg/kg- 5 male and 5 female
20 mg/kg-5 male and 5 female - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed daily and weight was taken on 0,7 and 14 day.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and pathology were observed - Statistics:
- No data available
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No deaths occurred of either sex during the observation period.
- Clinical signs:
- other: Hypo activity and loose stool was observed in both sexes as an effect of the test substance.
- Gross pathology:
- No significant change was observed in both sexes of treated group compared to control.
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 value was considered to be >2000 mg/kg in male and female Crj:CD(SD) rats for Toluene diisocyanate.
- Executive summary:
In a acute oral toxicity Crj:CD (SD) male and female rats were treated with Toluene diisocyanate in the concentration of 0 and 2000 mg/kg bw orally by gavage in corn oil and observed for 14 days. No effect on survival of treated male and female rats was observed as compared to control. In addition, no effect on body weight and gross pathology of treated male and female rats were observed as compared to control. Therefore, LD50 was considered to be > 2000 mg/kg bw when Crj:CD (SD) male and female rats were treated with Toluene diisocyanate orally by gavage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.