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EC number: 202-039-0 | CAS number: 91-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Appearance:
Based on available data from various reliable sources such as authoritative database and review article ,the chemical 2,6-Toluene diisocyanate was colorless to yellow liquid in appearance having pungent odour.
Other supporting studies from various reliable sources such authoritative database and handbooks also suggests that the chemical 2,6-Toluene diisocyanate was colorless to pale yellow colored liquid in appearance.
Freezing point:
Based on available data from various reliable sources such as authoritative database and handbooks,the freezing point of chemical 2,6-Toluene diisocyanate was determined to be 18.3 degree C.
Other suppoting study from reliable handbook and authoritative database suggests that the freezing point of chemical 2,6-Toluene diisocyanate was reported to be in the range of 7.2 degree C to 20 degree C and the seclected key study value lies between the range as mentioned above.
Boiling point:
Based on available data from various reliable sources such as authoritative database and handbook the boiling point of chemical 2,6-Toluene diisocyanate was determined to be in the range of 129 degree C to 133 degree C at 18 mm Hg pressure.
Other supporting study from authoritative database also suggests that the boiling point of chemical 2,6-Toluene diisocyanate was reported to be 130 degree C,which lies the range of selected key study.
Density:
Based on available data from authoritative database and review article ,the density of chemical 2,6-Toluene diisocyanate was determined to be 1.226 g/cm3 at 20 degree C.
Other supporting studies from authoritative database and review articles also suggests that the density and relative density of chemical 2,6-Toluene diisocyanate was reported to be 1.225 g/cm3 and 1.22 (water=1) respectively.
Particle Size Distribution:
In accordance with REACH Chapter R.7A Endpoint Specific Guidance, specifically R.7.1.14.1 Information requirements on granulometry, the granulometry study does not need to be conducted as the test substance, 2,6-Toluene diisocyanate is marketed or used in a non solid or granular form.The test substance, 2,6- Toluene diisocyanate is a colorless to yellow liquid at room temperature and as such this study is not technically feasible.Hence this endpoint was considered for waiver.
Vapour Pressure:
Data from various authoritative databases suggests that the experimental vapour pressure of 2,6- Toluene diisocyanate at 25 deg C was 0.0209 mmHg = 2.78 Pa.
Partition coefficient:
Data from authoritative and modelling databases suggests that the estimated logPow of 2,6- Toluene diisocyanate was 3.74
Water Solubility:
In accordance with Column 2 adaptation statement of REACH Annex VII, information requirement section 7.7, this study is not needed since the substance is (hydrolytically unstable at pH 4, 7 and 9 (t ½ <12 hr). The test substance; 2,6 -Toluenediisocyanate undergoes rapid hydrolysis in contact with water with a half life of less than 10 minutes.Hence this study is technically not feasible, therefore the endpoint can be considered for waiver.
Surface tension:
In accordance with Column 2 of Annex VII Section 7.6 of the REACH regulation, Testing may not be possible for reactive substances which react with water, as 2,6-Toluene diisocyanate (91-08-7) was reacts readily with water. Hence this study was considered for waiver.
Flash point:
As per the available data for flash point from authoritative database (Pubchem, CHRIP, Gestis,NIOSH,etc) the flash point value determined was in range from 110 degree C to 127 degree C. As more data available from databases which has K2 reliability having value as 127 °C thus considered as key study for the chemical safety assessment. Also based on criteria mentioned in CLP regulation the chemical has flash point >than 60 degree C hence the 2, 6-Toluene diisocyanate (91-08-7) was considered to be non-flammable.
Autoflammability:
From the available authoritative databases, the auto- ignition temperature of 2, 6-Toluene diisocyanate (91-08-7) was determined to be 620 degree C.
Flammability:
A study was performed to determine the flammable limits of 2,6-Toluene diisocyanate.
The lower explosion limits for 2,6-Toluene diisocyanate was 9.0 vol%.
Explosiveness:
In accordance with column 2 of Annex VII of the REACH regulation, the study does not need to be conducted since there are no chemical groups associated with explosive properties present in the molecule of 2,6- Toluene diisocyanate. Thus, the chemical is likely to be "Non explosive". Hence this end point was considered for waiver.
Oxidising Properties:
This study was not conducted since the chemical N-mrthylformanilide is incapable of reacting exothermically with combustible materials. Based on the chemical structure of 2,6- Toluene diisocyanate, the chemical contains oxygen but no halogen atoms and the oxygen is not chemically bonded to nitrogen. Thus, 2,6 - Toluene diisocyanate is not expected to have oxidising properties.
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