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Diss Factsheets
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EC number: 247-094-1 | CAS number: 25550-51-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Please refer to IUCLID Section 13. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- other: degradation to acid
- Value:
- ca. 100
- Sampling time:
- 4 min
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 2
- Sampling time:
- 28 d
- Key result
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- Biowin2 (Biodegrades Fast, p= 0.839), Biowin6 (Not Readily Degradable, p=0.440)
Reference
Description of key information
Ready biodegradability: 2% in 28 days
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Data are available for 4-methylhexahydrophthalic anhydride (4-MHHPA) whose structure is clearly close to methylhexahydrophthalic anhydride (MHHPA).
Ready biodegradability of 4-MHHPA by a non-adapted activated sludge has been investigated according to OECD/EU test methods using a Manometric Respirometry Test. After 28 days the mean biodegradation was 2% and the test substance must be regarded as not readily biodegradable. A toxicity control containing both test and reference substances demonstrated that degradation of the reference substance was not inhibited by the test substance indicating that the test substance is not inhibitory to STP microorganisms.
4-methylhexahydrophthalic anhydride (4-MHHPA) as well as methylhexahydrophthalic anhydride (MHHPA) hydrolyses almost instantaneously on contact with water, to give 4-methylhexahydrophthalic acid (4-MHHPAc, CAS 57567-84-7). A hydrolysis study according to OECD guideline no. 111 was carried out and the half-life (DT50) at pH 7 and 20°C was estimated to be 1.90 min.
The screening test inherent to the biodegradability of the acid degradation product 4 -MHHPAc was calculated using the software BIOWIN v4.10.The results indicate that 4-methylhexahydrophthalic acid is expected to be readily biodegradable.
Moreover, modelling of possible biodegradation pathways indicate that aerobic degradation is likely, intermediate degradation products being predicted which have been shown to be readily biodegradable.
Although QSAR estimations result in readily biodegradability environmental exposure was assessed by using the term “not biodegradable” as a worst case.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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