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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 233-135-0 | CAS number: 10043-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: I.p. administration is generally not recommended.
Data source
Reference
- Reference Type:
- publication
- Title:
- Assessment of genotoxicity of aluminium acetate in bone marrow, male germ cells and fetal liver cells of Swiss albino mice
- Author:
- D'Souza, Sr.P. et al.
- Year:
- 2 014
- Bibliographic source:
- Mutat Res Genet Toxicol Environ Mutagen 766:16 - 22
Materials and methods
- Principles of method if other than guideline:
- A sperm-abnormality assay was performed by treating male mice with a single dose and determining the frequency of abnormalities in sperm cells harvested 5 weeks later.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Bis(acetato-O)hydroxyaluminium
- EC Number:
- 205-518-2
- EC Name:
- Bis(acetato-O)hydroxyaluminium
- Cas Number:
- 142-03-0
- IUPAC Name:
- aluminum hydroxide diacetate
- Details on test material:
- - Name of test material (as cited in study report): aluminium acetate, C₆H₉AlO₆
- Physical state: white, light hygroscopic powder
- Analytical purity: no data
- Lot/batch No.: 1049
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: departmental animal house of the Department of Applied Zoology, Mangalore University, Mangalagangothri, India
- Age at study initiation: 8 - 10 weeks
- Weight at study initiation: 25 ± 2 g
- Diet: commercial food pellets (Amrutha feeds, Bangaloer, India), ad libitum
- Water: unspecified source, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 2
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Remarks:
- double distilled
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- single treatment
- Frequency of treatment:
- single treatment
- Duration of test:
- 5 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 100 and 150 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 5 males
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Eight-week-old virgin male mice were used. Post-treatment sampling was done after five weeks considering the duration required for spermatogenesis, and for sperm reaching the cauda epididymis. Sperm suspensions were made in phosphate-buffered saline (pH7.2) from both caudae and stained with 1% eosin-Y.
A total of 2000 sperm per animal were scored to determine the frequency of sperm abnormalities, which include hookless, amorphous, banana-shaped, folded, double-headed and double-tailed. The frequency of abnormal sperm was expressed as percentage, calculated with the formula: [number of abnormal sperm - total number of normal and abnormal sperm scored] × 100. In addition, testes weight and sperm count per epididymis were determined.
The positive control was 0.2 mL cyclophosphamide via intraperitoneal injection (50 mg/kg bw). - Statistics:
- Statistical analysis of the data was performed by means of the paired t-test. A P-value < 0.05 was considered to correspond with statistical significance.
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 50 other: mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: Increased percentage abnormal sperm
Observed effects
Any other information on results incl. tables
Table 1: Frequency of different types of abnormal sperm induced in Swiss albino mice after five weeks of treatment with aluminium acetate*
Dose (mg/kg bw) |
A |
B |
H |
F |
DH |
DT |
Total abnormal |
% abnormal sperm ± SEM |
Control |
33 |
8 |
31 |
26 |
2 |
7 |
107 |
1.07 ± 0.26 |
50 CP |
182 |
43 |
149 |
100 |
12 |
25 |
511 |
5.11 ± 0.59c |
50 Al |
89 |
28 |
46 |
36 |
6 |
12 |
217 |
2.17 ± 0.31a |
100 Al |
115 |
62 |
48 |
57 |
5 |
25 |
312 |
3.12 ± 0.76b |
150 Al |
121 |
52 |
54 |
79 |
22 |
23 |
351 |
3.51 ± 0.81b |
A, amorphous; B, banana shaped; H, hookless, F, folded; DH, double headed; DT, double tailed. (a)P < 0.05, (b)P < 0.01, (c)P < 0.001 (paired t-test). * 2000 sperm/animal. Al = aluminium acetate.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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