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Diss Factsheets
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EC number: 201-202-3 | CAS number: 79-39-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity
- Remarks:
- intraperitoneal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Peer reviewed in OECD SIDS. No GLP. Dose dependency was not clear because methacrylamide was administered at one dose level. Descriptions about animal husbandry including barrier system were not reported. Therefore the reliability of this study was considered limited.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studium der Lungentumorbildung bei Mäusen durch Methacrylamid.
- Author:
- Matsuda H
- Year:
- 1 989
- Bibliographic source:
- Kanazawa Daigaku Juzen Igakkai Zasshi 98(2): 428-438; translated on behalf of Röhm GmbH
Materials and methods
- Principles of method if other than guideline:
- Method: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Methacrylamide
- EC Number:
- 201-202-3
- EC Name:
- Methacrylamide
- Cas Number:
- 79-39-0
- Molecular formula:
- C4H7NO
- IUPAC Name:
- methacrylamide
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Purity of the test substance: no data
Test animals
- Species:
- mouse
- Strain:
- other: ddY
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- daily (first group) or 5 times every second day (second group)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
200 mg/kg in aqueous solution
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 6 months
Results and discussion
Any other information on results incl. tables
Results:
In the first dose group in 16 of 57 (28%) mice and in the second dose group in 8 of 38 (21%) mice, an increased number of lung adenoma were found. Control (1 out of 48 (2.1%) lung tumor formation was found. After 3 hours it was shown with radiolabelled 14C-methacrylamide that the highest
concentrations of methacrylamide were found in the kidneys, followed by liver, blood, spleen and lungs. Approx. 5 % of the radiolabelled methacrylamide in the
lung was bound to the protein fraction. A direct alkylation of nucleosides in vitro was not observed. The lipid peroxidation of the microsomes was neither affected in vitro nor in vivo.
Histopathology of tumors: All tumors were identified as adenoma resulting from alveolar type II epithelial cells.
Control group: After 6 months, 1 of 48 animals had a tumor. Dose dependency was not clear because methacrylamide was administered at one dose level. Descriptions about animal husbandry including barrier system were not reported. Therefore the reliability of this study was considered limited.
Applicant's summary and conclusion
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