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EC number: 201-202-3 | CAS number: 79-39-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Japanese government peer-reviewed the documents, audited selected studies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Supplier: KISHIDA CHEMICALS CO., Ltd (Lot No. D12358J)
Purity: >= 98 % - Analytical monitoring:
- yes
- Details on sampling:
- SAMPLING: daily during exposure
- Vehicle:
- no
- Details on test solutions:
- Dilution water: medium on OECD Test guideline 211
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Test Organism:
-supplier; National Institute of Environmental Studies (Japan)
-age; juvenile Daphnia magna less than 24hr old
–feeding during acclimation: Chlorella vulgaris, 0.1 - 0.2 mgC/day/individual
–acclimation: 3-4 weeks
–feeding during test: Chlorella vulgaris, 0.1 - 0.2 mgC/day/individual - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 21 d
- Hardness:
- 245 mg/l as CaCO3
- Test temperature:
- 19 - 21 °C
- pH:
- 7.6
- Salinity:
- no data
- Nominal and measured concentrations:
- 0, 100.0 mg/L nominal (actual concentration measured and greater than 80% of the nominal)
- Details on test conditions:
- TEST SYSTEM
-renewal of test solution: 3 times a week
-exposure vessel type: 80 mL test solution in a 100 mL glass vessel
-number of replicates/individual per replicate: 10/1
-intensity of irradiation: room light
-photoperiod: 16hr - 8hr light-dark cycle - Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- Results: Table 1 NOMINAL/MEASURED CONCENTRATION:
-----------------------------------------------------------
Nominal Measured conc. (mg/L) Time
conc. 0day 2day 6day 8day 15day 17day weighted
* ** * ** * ** mean
-----------------------------------------------------------
Control <0.5 <0.5 <0.5 <0.5 <0.5 <0.5 <0.5
100.0mg/L 92.5 91.3 99.5 93.6 104.1 100.2 96.9 %
of nominal 92.5 91.3 99.5 93.6 104.1 100.2 96.9
-----------------------------------------------------------
* : freshly prepared test solution
**: test solution after 48hr exposure period
EFFECT DATA (PARENTS)
21day LC50 > 100.0 mg/L
EFFECT DATA (REPRODUCTION)
21day EC50 > 100.0 mg/L
21day NOEC > 100.0 mg/L
21day LOEC > 100.0 mg/L
Table 2 CUMULATIVE NUMBERS OF DEAD PARENTAL DAPHNIA AND
MORTALITY AFTER EXPOSURE OF 21DAY
-----------------------------------------------------------
Nominal Conc. Number of dead Mortality (%)
-----------------------------------------------------------
Control 1 10
100.0 mg/L 2 20
-----------------------------------------------------------
Table 3 TIME (day) TO FIRST BROOD PRODUCTION
-----------------------------------------------------------
Nominal Conc. vessel no. Mean day
1 2 3 4 5 6 7 8 9 10
-----------------------------------------------------------
Control 8 11 7 18 8 20 13 10 - 11 11.8
100.0mg/L 13 17 - 8 11 7 11 17 11 - 11.9
-----------------------------------------------------------
Table 4 MEAN CUMULATIVE NUMBER OF JUVENILES PRODUCED PER ADULT AND
INHIBITION RATE DURING EXPOSURE
-----------------------------------------------------------
Nominal DAY
Conc. 1-6 7 8 9 10 11 12 13 14 15 16
-----------------------------------------------------------
Control 0.0 0.2 0.9 0.9 1.3 4.0 4.0 12.4 18.4 18.4 25.4
100.mg/L0.0 0.4 0.9 0.9 0.9 3.8 3.8 4.8 6.8 6.8 6.8
-----------------------------------------------------------
-----------------------------------------------------------
Nominal DAY mean+/-S.D. Inhibition
Conc.17 18 19 20 21 rate (%)
-----------------------------------------------------------
Control 39.1 39.4 43.8 64.2 66.6 66.6+/-39.72 -
100.0mg/L 31.6 31.6 31.6 66.1 66.1 66.1+/-16.85 0.8
-----------------------------------------------------------
Table 5 CUMULATIVE NUMBER OF JUVENILES PRODUCED PER
ADULT DURING EXPOSURE
-------------------------------------------------------------------------------------------------
Nominal Conc. vessel no. Total
1 2 3 4 5 6 7 8 9 10
------------------------------------------------------------------------------------------------
Control 51 71 42 24 109 7 114 66 - 115 599
100.0mg/L 39 74 - 51 57 78 92 64 74 - 529
------------------------------------------------------------------------------------------------
NUMBER OF WINTER EGGS DURING EXPOSURE
none of winter eggs at Control and 100.0 mg/L - Results with reference substance (positive control):
- EiC50 (48hrs) = 0.60 mg/l , K2Cr2O7
- Reported statistics and error estimates:
- Statistics: F&t-test; Yukms StatLight#3 "Pairwise Comparison"
- Validity criteria fulfilled:
- yes
- Conclusions:
- Methacrylamide was tested in a Daphnia magna Reproduction test, OECD 211, 21 d. The NOEC of reproduction is > 100 mg/l (measuerd and nominal)
- Executive summary:
The 21-day-chronic toxicity of methacrylamide to Daphnia magna was studied under static renewal conditions. Daphnids were exposed to control and test chemical at nominal/measured concentrations of 100 mg a.i./L. The 21 day LC50/EC50based on mortality/sublethal effect was > 100 mg a.i./L. The 21-day NOEC based on sublethal effect was >100 mg a.i./L. The sublethal effects included were reproduction. Production of offsprings in the treated groups indicated that methacrylamide did not have an effect on the reproduction at concentrations greater than > 100 mg a.i./L.
This study is classified as acceptable and satisfies the guideline requirements for a chronic toxicity study with freshwater invertebrates.
Results Synopsis
Test organism: juvenile Daphnia magna less than 24 hr old
Test type: Static renewal
Reference
Description of key information
The 21-day-chronic toxicity of methacrylamide to Daphnia magna was studied under static renewal conditions. Daphnids were exposed to control and test chemical at nominal/measured concentrations of 100 mg a.i./L. The 21 day LC50/EC50based on mortality/sublethal effect was > 100 mg a.i./L. The 21-day NOEC based on sublethal effect was >100 mg a.i./L. The sublethal effects included were reproduction. Production of offsprings in the treated groups indicated that methacrylamide did not have an effect on the reproduction at concentrations greater than > 100 mg a.i./L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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