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Diss Factsheets
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EC number: 205-426-2 | CAS number: 140-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, identification of test substance does not allow to differenciate whether it was the straight-chain or branched-chain form of octanol. This is however considered irrelevant for this endpoint.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- yes (only 7 days observation, 2 dose levels only, 3 animals per sex and dose only)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- p-octylphenol
- EC Number:
- 217-302-5
- EC Name:
- p-octylphenol
- Cas Number:
- 1806-26-4
- IUPAC Name:
- 4-octylphenol
- Reference substance name:
- 79/298
- IUPAC Name:
- 79/298
- Details on test material:
- Identified by trade name and by a structural formula (alkylchain only indicated as C8H17 which might be either straight-chain or branched).
purity: ca. 95 %
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- males: 2,9 kg
females: 3,1 kg
Ssniff K, Standard diet ad libitum
Shaving was done prior to application to back and flank, approximately 230 cm2
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- The substance was administrated on skin. Thereafter, skin was covered with an inert foil for 24h. After exposure, skin was rinsed with water or a 1:1 mixture of water and polyethylenglykol 400
- Duration of exposure:
- 24h
- Doses:
- 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not required
- Details on study design:
- post-observation for 7 days
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Remarks on result:
- other: skin irritation, no necropsy findings
- Mortality:
- none
- Clinical signs:
- other: There were observations of a transition towards leather-like necrosis and persistent oedema after 24h as well as apathy and tremor. After 7 days, formation of scabs was observed and animals felt well.
- Gross pathology:
- no findings
- Other findings:
- no findings
Applicant's summary and conclusion
- Interpretation of results:
- other: not toxic, but highly irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD 50 to rabbits of substance 79/298 was found to be greater than 2000 mg / kg bw. The substance is not toxic and not corrosive. But due to skin irritation observed in 2 studies substance 79/298 has to be classified as irritant (Xi, R38).
- Executive summary:
The acute dermal LD50 of substance 79/298 in rabbits of both sexes observed over a period of 7 days was found to be greater than 2000 mg/kg bw. No mortalities were observed, gross pathology was without findings. Observation revealed no signs of systemic effects, no full thickness destruction of skin tissue but skin irritation. Substance 79/298 causes erythema, oedema and necrotic skin alterations. However, sqamation and formation of scabs was observed, suggesting recovery of skin alterations. Especially the dermal irritation study described development of intact skin under removed scabs.
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