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Diss Factsheets
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EC number: 205-426-2 | CAS number: 140-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence Assessment
4-tert-Octylphenol has been shown to be inherently biodegradable (28-day BODIS test) with 20% mineralisation during the 28-day study and in another case meets the criteria for ready biodegradability but failing the 10-day window (OECD 301B test) with 62% degradation after 28 days. A modified MITI test resulted in minimal degradation, although this study is considered to be less reliable and realistic than the ready biodegradability study. According to Regulation (EC) No 1907/2006 (REACH) ANNEX XIII and the Guidance on information requirements and chemical safety assessment, Chapter R.11 (PBT Assessment), the substance does not fulfill the screening criterion “persistent (P)” and “very persistent (vP)” as within the OECD 301B test the substance is shown to be degradable at a rate of more than 60% within 28 days.
4-tert-octylphenol is also biodegradable and unlikely to persist in freshwater sediments, marine sediments and soils, where these compartments are aerobic, although the substance may be considered to be persistent in anoxic sediments.
Bioaccumulation Assessment
According to Annex XIII of Regulation (EC) No 1907/2006 and to the Guidance on information requirements and chemical safety assessment Chapter R.11 (PBT Assessment), a substance does not fulfill the criterion “bioaccumulative (B)” or “very bioaccumulative (vB)” if the BCF is below 2000 or 5000 respectively or the log Kow is below 4.5.The reliablebioconcentration study for4-tert-octylphenol (Tsuda et al,2001)reported aBCF result of 261, based on whole body wet weight, forOryzias latipes. Supporting evidence from the read-across substance nonylphenol for juvenile fish reported BCF of 231 and 740 (whole body wet weight). A calculated BCFearthwormof 758 shows octylphenol is unlikely to accumulate through terrestrial food chains. In accordance with Annex XIII of Regulation (EC) No 1907/2006,4-tert-octylphenoldoes not fulfil the criteria “bioaccumulative (B)” or “very bioaccumulative (vB)”asthe bioconcentration factor (BCF) issubstantiallybelow 2000 and 5000.No further testing is required to conclude on the bioaccumulation criterion.
Toxicity Assessment
A review of the toxicity test results for exposure of aquatic organisms resulted in reliable data from studies that included freshwater species and saltwater species representing fish, invertebrates, algae, and a snail. Short-term (acute) exposures of octylphenol to freshwater and marine invertebrates ranged from 0.019 to 0.11 mg octylphenol/L. The freshwater test organism (Gammarus pulex) may be more sensitive to effects on immobility and survival than the marine organism tested (Mysidopsis bahia). Fish species were generally found to be less sensitive to short-term octylphenol exposure than invertebrate organisms. Short-term survival LC50 values were >0.1 mg octylphenol/L for both fresh and saltwater test species. Other organisms tested included short-term octylphenol exposure to algae (Pseudokirchneriella subcapitataformerlySelenastrum capricornutum) and a mixed culture of microorganisms from activated sludge, both of which were markedly less sensitive to toxic effects of octylphenol than all other species tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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