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Diss Factsheets
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EC number: 201-279-3 | CAS number: 80-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Toxicity to fish
Data from acute toxicity testing towards fish can be interpreted in a weight of evidence approach that dicumyl peroxide showed no effects at maximum water solubility. This is in line with a recent study on acute toxicity towards daphnia, where no effects were observed in water accommodated fraction (test solution prepared without solvent, but reaching maximum water solubility).
According to Annex IX of Regulation (EC) No 1907/2006 chronic fish toxicity tests should be proposed if the chemical safety assessment indicates the need to investigate further the effects on fish. However, overall information is sufficient for risk assessment. Therefore, testing of on chronic fish toxicity is not regarded necessary.
Toxicity to aquatic invertebrates
Data from acute toxicity testing towards Daphnia indicate that dicumyl peroxide showed no effects at maximum water solubility.
The 21-day-chronic toxicity of dicumyl peroxide to Daphnia magna was studied under static renewal conditions. The parental 21-day LC50 based on mortality was 0.195 mg/L, the 21-day EC50 for reproduction was 0.231 mg/L. The 21-day NOEC based on average cumulative number of brood was 0.117 mg/L, the 21-day LOEC was 0.247 mg/L. Sublethal effects were observed in the 0.247 mg/L plot (body colour brightening and growth inhibition, besides lethargy, immobility, and activity drop). No symptoms were observed in the other concentration plots. Dead larvae were observed in all the test plots, and the 0.247 mg/L plot had somewhat more than the control plot. Fallen eggs were also observed in all of the test plots, the 0.117 mg/L showed a statistically significant difference. Production of offspring in the treated groups indicated that dicumyl peroxide had an effect on the reproduction at concentrations greater than 0.117 mg/L. The most sensitive end point was reproduction.
Toxicity to algae
In a 72 hour acute toxicity study, the cultures of Pseudokirchneriella subcapitata (reported as Selenastrum capricornutum), strain ATCC 22662, were exposed to dicumyl peroxide. The 72h EbC50 and 72h NOEbC values based on cell density were > 20 mg/L and 3.20 mg/L, respectively (nominal). The 24-48 h ErC50 and the 24-72 h ErC50 were both > 20 mg/L, whereas the 24-48 h NOEC and 24-72 h NOEC values based on growth rate were 8 mg/L, each (nominal).
These results are supported by a second study. Effect concentrations based on growth rate of cultures of Selenastrum capricornutum (new name: Pseudokirchneriella subcapitata) were ErC50 > 1000 mg/L and NOEC (growth rate): 10 mg/L, respectively. The effect concentration based on biomass was EC50 > 1000 mg/L. The NOEC for biomass was not determined in this test, but was < 10 mg/L.
Both studies indicate no effect at maximum water solubility.
Toxicity to micro-organisms
In an activated sludge respiration inhibition test, secondary activated sludge of a predominantly domestic sewage treatment plant was exposed to dicumyl peroxide adsorbed on silica gel at a concentration 1000 mg/L (nominal) under static conditions for 30 min in accordance with OECD guideline 209 (activated sludge, respiration inhibition test). The NOEC based on respiration inhibition was >1000 mg/L.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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