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EC number: 204-886-1 | CAS number: 128-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- density, other
- Remarks:
- density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17/2/2016-17/2/2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Experimental test result performed using standard test guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Principles of method if other than guideline:
- The density of test item 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt (CAS No. 128-44-9) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.
- GLP compliance:
- no
- Type of method:
- pycnometer method
- Specific details on test material used for the study:
- - Name of test material: 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- IUPAC name: 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- Molecular formula: C7H4NNaO3S
- Molecular weight: 205.169 g/mole
- Smiles: c12c(C(=O)[NH-]S1(=O)=O)cccc2.[Na+]
- InChI: 1S/C7H5NO3S.Na/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;/h1-4H,(H,8,9);/q;+1/p-1
- Substance type: organic
- Physical state: Solid crystalline powder (white)
- Purity: 99.66% - Key result
- Type:
- pour density
- Density:
- 0.871 g/cm³
- Temp.:
- 27.4 °C
- Remarks on result:
- other: At 979 hPa.
- Key result
- Type:
- tap density
- Density:
- 0.909 g/cm³
- Temp.:
- 27.4 °C
- Remarks on result:
- other: At 979 hPa.
- Conclusions:
- The pour density and tapped of test item 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt (CAS No. 128-44-9) was determined following OECD Guideline 109 and according to the according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014 using bulk density apparatus . The pour density and tapped density of the test item was determine to be 0.8711 g/cm3 and 0.9090 g/cm3 at 27.4 Deg C and 979 hPa.
- Executive summary:
The density of test item1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt(CAS No. 128-44-9) was determined following OECD guideline 109 and according to themethod recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.8711 g/cm3 and 0.9090 g/cm3 at 27.4oC and 979 hPa.
Reference
Method Details |
Observations |
Remarks if, any |
||
Guideline |
OECD 109 |
1stReading |
2ndReading |
|
|
|
|||
Method |
Test methods: Pour density and tapped density of powders”recommended inThe International Pharmacopoeia, Fourth Edition, 2014[1] |
|
|
|
Principle of method |
Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density:It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder. |
|
|
|
Test temperature (°C) |
- |
27°C |
27.8°C |
|
Atmospheric pressure (in hPa) |
- |
978.9 hPa |
979.1hPa |
|
Weight of test item(m) |
|
20 g |
20 g |
|
Volume of measuring cylinder; readability in g |
|
250 ml;2 ml |
250 ml ;2 ml |
|
Volume of test item without tapping (V) |
|
24 ml |
22 ml |
|
Volume of test item after tapping ( V1) |
After 10 tapping |
22 ml |
22ml |
|
|
After 50 tapping |
22 ml |
22ml |
|
|
After 100 tapping |
---- |
------ |
|
|
After 250 tapping |
---- |
------ |
|
|
After 500 tapping |
---- |
------ |
|
|
After 750 Tapping |
---- |
------ |
Description of key information
The density of test item1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt(CAS No. 128-44-9) was determined following OECD guideline 109 and according to themethod recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.8711 g/cm3 and 0.9090 g/cm3 at 27.4oC and 979 hPa.
Key value for chemical safety assessment
Additional information
The density of test item1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt(CAS No. 128-44-9) was determined following OECD guideline 109 and according to themethod recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.8711 g/cm3 and 0.9090 g/cm3 at 27.4oC and 979 hPa.
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