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EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
“In water, phosphoryl trichloride hydrolyzes to phosphoric acid and hydrochloric acid with t1/2 < 10 seconds (Riess, 2002): POCl3 + 3 H2O → H3PO4 + 3 HCl” (OECD SIDS for phosphoryl trichloride, 2004).
The corresponding pH value of phosphoryl trichloride at 25 °C is approximately 1 (at 5 g/L).
Further testing is not required on scientific grounds and for reasons of animal welfare. However, the available data for phosphoryl trichloride are reported.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Summary of non-standard study; adequate for the purposes of classification
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation of the irritant effects of a transient dermal exposure and assessment of the efficacy of decontamination.
- GLP compliance:
- not specified
- Remarks:
- : summary report only
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 60 seconds
- Observation period:
- Not reported
- Number of animals:
- Not reported
- Irritation parameter:
- other: details are not reported
- Reversibility:
- no data
- Remarks on result:
- other: signs of severe skin irritation or corrosion were noted
- Other effects:
- Depending on the decontamination method, the substance is reported to be either a severe irritant or corrosive to skin.
- Interpretation of results:
- other: corrosive
- Conclusions:
- Application of phosphoryl trichloride to skin resulted in severe irritation or corrosive effects.
- Executive summary:
100 µl of phosphoryl trichloride applied to shaved rabbit skin for 60 seconds resulted in severe skin irritation or corrosive effects.
Reference
Depending on the decontamination method, the substance is reported to be either a severe irritant or corrosive to skin.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation/corrosion:
Phosphoryl trichloride was found to cause corrosive effects in a skin irritation study (Imlay, 1977). Similar effects are reported in studies by Birch (1978) and Molodkina (1973). A study summary (Pauluhn, 1984) reports corrosive effects within 60 seconds of the dermal application of 100 µl phosphoryl trichloride.
Eye irritation:
Severe reactions seen in an eye irritation study (Imlay, 1977) were confirmed in other studies by Birch (1978) and Molodkina (1973).
Respiratory irritation:
Phosphoryl trichloride reacts with water, forming hydrochloric acid and phosphoric acid. Due to this hydrolytic reaction, phosphoryl trichloride is corrosive to the skin, eyes and respiratory tract. The acute toxicity of phosphoryl trichloride following inhalation is high. The 4h-LC50 of phosphoryl trichloride is 48.4 ppm (308 mg/m³) to 11.1 ppm (71 mg/m³) for rats and 52.5 ppm (335 mg/m³) for guinea pigs. Clinical signs included severe respiratory tract irritation, nasal discharge and eye irritation.
Justification for selection of skin irritation / corrosion
endpoint:
The study of Pauluhn (1984) reports corrosive effects within 60
seconds of the dermal application of 100 µl phosphoryl trichloride.
Justification for selection of eye irritation endpoint:
Several limited studies reported irritant/corrosive effects on the
eyes of rabbits.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: irreversible effects on the eye
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
Phosphoryl trichloride is listed on Annex VI of Regulation (EC) No 1272/2008 with classification as Skin corr. 1A, H314: Causes severe skin burns and eye damage. No change to this classification is proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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