Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Justification for type of information:
- Data from structural related substance (see attached justification)
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- other: Histopathological examination of all major organs in a 90 day inhalation study with hydrogen chloride
- Adequacy of study:
- other information
- Reliability:
- other: Histopathological examination of all major organs in a 90 day inhalation study with hydrogen chloride
- Species:
- rat
- Sex:
- male/female
- Dose descriptor:
- NOAEL
- Effect level:
- 20 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: see Remarks
- Conclusions:
- Daily exposure of rats to gaseous hydrogen chloride at concentrations of 10, 20 and 50 ppm, 6 hours a day, 5 days per week up to a 90 day exposure period affected the body weight of males of one of the strains of rats at the highest dose level. Clinical signs observed were mainly related to the irritant/corrosive properties of hydrogen chloride: crusty nose, red or yellow/brown stained fur, poor quality coat, crusty eye(s) and nasal discharge in rats. No exposure-related changes were seen in haematology or clinical chemistry parameters or urinalysis, and no peculiar gross observations were noted at necropsy. Decreased liver weights and increases in other organs were recorded, but these changes were considered to be mainly related to the effect of treatment on general growth of the affected animals rather than direct effects on the organs themselves.
Histopathological examination after 90 days exposure revealed minimal to mild rhinitis in both strains of rats.
Based on effects on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.
Based on the lack of effects on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.
Histopathological examination after 90 days exposure revealed minimal to mild rhinitis in both strains of rats.
Based on effects on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.
Based on the lack of effects on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.
Data source
Materials and methods
Test material
- Reference substance name:
- Phosphoryl trichloride
- EC Number:
- 233-046-7
- EC Name:
- Phosphoryl trichloride
- Cas Number:
- 10025-87-3
- Molecular formula:
- Cl3OP
- IUPAC Name:
- phosphoroyl trichloride
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 20 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: see Remarks
Observed effects
Histopathological examination after 90 days exposure revealed minimal to mild rhinitis in both strains of rats.
Based on effects on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.
Based on the lack of effects on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.
Applicant's summary and conclusion
- Conclusions:
- Based on effects on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.
Based on the lack of effects on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.
Phosphoryl trichloride hydrolyzes in water within seconds, forming phosphoric acid and hydrochloric acid (t1/2 < 10 seconds) (Hansel, 2004). Toxicological effects are expected mostly from exposure to these degradation products.
Therefore, a read-across with the degradation products is justified (see attached justification: Justification for a read-across of Phosphoryl trichloride (CAS no. 10025-87-3, EC no. 233-046-7) [Target] and its hydrolysis products phosphoric acid (CAS no. 7664-38-2, EC no. 231-633-2) [Source] and hydrochloric acid (CAS no. 7647-01-0, EC no. 231-595-7) [Source] concerning toxicity and ecotoxicity). - Executive summary:
Phosphoryl trichloride hydrolyzes in water within seconds, forming phosphoric acid and hydrochloric acid (t1/2 < 10 seconds) (Hansel, 2004). Toxicological effects are expected mostly from exposure to these degradation products.
Therefore, a read-across with the degradation products is justified (see attached justification: Justification for a read-across of Phosphoryl trichloride (CAS no. 10025-87-3, EC no. 233-046-7) [Target] and its hydrolysis products phosphoric acid (CAS no. 7664-38-2, EC no. 231-633-2) [Source] and hydrochloric acid (CAS no. 7647-01-0, EC no. 231-595-7) [Source] concerning toxicity and ecotoxicity).
Based on effects of hydrogen chloride on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.
Based on the lack of effects of hydrogen chloride on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.