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Diss Factsheets
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EC number: 231-891-6 | CAS number: 7775-19-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15-03-1998 to 24-03-1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium metaborate dihydrate
- Cas Number:
- 16800-11-6
- Molecular formula:
- NaBO2*2H2O
- IUPAC Name:
- Sodium metaborate dihydrate
- Details on test material:
- - Name of test material: Sodium metaborate mol 4.
- Physical state: White powder
- Analytical purity: > 99 %
- Storage condition of test material: Room teperature in the dark in the original container.
- Other: Unique dispensary No. 0603/95-1341
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Uk, Ltd.
- Age at study initiation: 14 - 19 weeks old
- Weight at study initiation: 2.8 - 3.84 kg
- Housing: In floor pens accommodating one animal throughout the acclimatisation and experimental phases.
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: A period of between 5 and 7 weeks.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 - 22 °C
- Humidity (%): Humidity was not actively controlled, but was expected to remain within the range of 40 to 80 % RH.
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 h dark/12 h light.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: Clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 500 mg. Skin was moistened with water prior to application. - Duration of treatment / exposure:
- The sentinal was dosed for 3 min, 1 h and 4 h.
Two further rabbits were subjected to single 4 h applications. - Observation period:
- Three days
- Number of animals:
- Three
- Details on study design:
- TEST SITE
- Area of exposure: 30 x 20 mm
- Type of wrap if used: The test sites were covered iwth a dense gauze patch (30 x 20 mm) which was in turn covered by a larger gauze patch (40 x 40 mm) and an open-weave, elasticated adhesive bandage which was wrapped firmly around the torso to secure the applied dose and patch to the correct position.
REMOVAL OF TEST SUBSTANCE
- Washing: On removal of the patches the treated skin was lightly brushed clean of any solid residue and swabbed with moist cotton wool.
- Time after start of exposure: The sentinal was dosed for 3 min, 1 h and 4 h. Two further rabbits were subjected to single 4 h applications.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: Not applicable
- Irritant / corrosive response data:
- There were no irritation reactions or other dermal changes following single, semi-occluded topical applications of the test article to skin for 4 h.
- Other effects:
- There were no signs of toxicity or ill health in any rabbit during the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- other: EU GHS criteria not met
- Conclusions:
- A single semi-occluded application of sodium metaborate 4 mol to intact rabbit skin for 4 h did not elicit any irritation reacions or other dermal changes.
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