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EC number: 221-950-4 | CAS number: 3290-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The NOEC of TMPTMA on time to hatch and hatching success in fathead minnows is =1.431 mg/L. The NOEC for mortality, body weight and fry length is 0.138 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.138 mg/L
Additional information
The effects of prolonged exposure to Propylidynetrimethyl Trimethacrylate (EC/CAS N. 221 -950 -4/3290 -92 -4) on the early life stages of the fathead minnow (Pimephales promelas) were assessed over embryo development, hatching and for 28 days post-hatch, in accordance with OECD Guideline 210 (1992).
The definitive test was conducted under continuous flow conditions, with embryos (<24 h old) exposed to the following nominal concentrations: 0.02, 0.064, 0.2, 0.64 and 2 mg/L of TMPTMA. Both solvent and non-solvent controls were included in the test. Chemical analysis of test samples taken during the exposure phase indicated that measured concentrations of TMPTMA were not maintained at 80-120% of nominal, at all test concentrations over the test period. The geometric mean measured concentrations of TMPTMA were calculated as 0.017, 0.052, 0.138, 0.442 and 1.431 mg/L for the respective nominal concentrations of 0.02, 0.064, 0.2, 0.64 and 2 mg/L.
Statistical analysis indicated a significantly higher mortality in the 0.442 and 1.431 mg/L treated groups than in the solvent control. There was no significant difference in mortality between the 0.017, 0.052 and 0.138 mg/L treated groups and the solvent control. The LC5,LC10,LC20 and LC50 values were estimated to be 0.051, 0.074, 0.117 and 0.276 mg/L, respectively. The NOEC for mortality is concluded to be 0.138 mg/L; the corresponding LOEC is concluded to be 0.442 mg/L.
Fry length and body weight were measured at the end of the test. Statistical analysis indicated no significant differences in length and body weight between the 0.017, 0.052 and 0.138mg/L treatment groups and the solvent control group. There was however a significant difference between the 0.442 mg/L treatment group and the solvent control. The NOEC for effect on length and body weight loss is therefore concluded to be 0.138 mg/L; the corresponding LOEC for effect on length and body weight loss is concluded to be 0.442 mg/L.
Based on the above results, mortality, fry length and body weight appear to be the most sensitive parameters in the early life stage test of the fathead minnow, with the NOEC for TMPTMA being 0.138 mg/L. As no significant mortalities were at the lower concentrations than 0.138 mg/L (geometric mean measured concentrations), LC10 was appraised from a too low number of data to be reliable. Therefore, the NOEC for mortality (0.138 mg/L) was used for Chemical Safety Assessment (CSA).
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