Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 221-950-4 | CAS number: 3290-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_classification-and-labelling-and-pbt-assessment.png)
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
In a CO2 evolution test conducted according to OECD guideline 301B, the test substance was biodegraded at 53% after 28 days. According to these results, the test item showed an high potential for biodegradation even if it did not fulfill the criterion to be readily biodegradable. In addition, the biodegradation potential of the test substance was assessed using an in-silico approach (supporting study), the BOD QSAR Model “LMC OASIS CATALOGIC 301C”. This model also identifies the likely biotic degradation products of the test substance. The in silico approach was chosen as an appropriate method to assess the degradation products and to conduct a screening assessment of their persistence potential. The parent substance was predicted as not readily biodegradable, which confirms the results of the available experimental ready biodegradation study. In addition, the primary half life was calculated as 2.79 days and the ultimate half-life value was equal to 21.91 days. These results indicate that none of the assessed substances (parent substance and its degradation products) are likely to persist in the environment. The substance and its degradation products cannot be considered persistent nor very persistent.
Furthermore, as the substance is not P/vP and the measured log Kow of the test substance is lower than the screening B properties threshold of 4.5 (measured log Kow = 4.19), no further B assessment is considered necessary. Nevertheless, a well-documented and reliable QSAR approach is provided in order to evaluate the bioaccumulation potential of the test substance. The bioaccumulation potential of the substance in fish was estimated using the OASIS CATALOGIC BCF model (OASIS LMC, 2022). The Log BCF was calculated as 0.72, which corresponds to a BCF value of 5.25 L/kg ww. This value is clearly below the screening threshold of 2000 L/kg. Therefore, the test substance cannot be considered B nor vB.
In conclusion, the test substance is not classified as PBT and not vPvB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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