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EC number: 421-820-9 | CAS number: 192268-65-8 CD 28-0132; IRGALUBE 232
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance is of low acute oral and acute dermal toxicity with LD 50s higher than 2000 mg/kg bw, respectively. The tests were performed pursuant to EU Method B.1 (Acute Toxicity (Oral)) 92/69/EEC and OECD Guideline 402 (Acute Dermal Toxicity), respectively. Experimental data on acute inhalation toxicity is not available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- valid without restriction
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- valid without restriction
Additional information
Oral Route of Exposure
In the key study performed according to the protocols of EU Method B.1 (Acute Toxicity (Oral)), groups of Sprague Dawley rats (5 rats/sex/dose) were given a single oral dose (gavage) of the test article at the dose level 2000 mg/kg bw. The animals were observed subsequently for a period of 14 days. No mortality occurred during the14 day observation period. Piloerection which is a common finding in acute toxicity tests was the only clinical sign of systemic toxicity manifested by the test animals. Piloerection was present for up to 4 days following gavage. At necropsy, no gross lesions were observed. As no deaths occurred in the study, the LD 50 of the test article in rats is higher than 2000 mg/kg bw (Huntingdon Life Sciences Limited 1995).
Dermal Route of Exposure
In a limit test performed pursuant to the protocols of the OECD Test Guideline 402, the test article (no data on analytical purity) was applied in a semi-occlusive fashion for 24 hours to the shaved skin of 5 (8 -11 weeks old) Hanlbm: WIST rats/sex at a dose level of 2000 mg/kg bw. Animals were then observed for 14 days. No mortality was registered in the study. Neither clinical signs of systemic toxicity nor local irritation effects at the application site were observed during the 14 day observation period. Necropsy revealed no gross abnormalities. As no deaths occurred in the study, the LD 50 of the test article in rats is higher than 2000 mg/kg bw (RCC Ltd. 1997).
Inhalation Route of Exposure
No data available
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are reliable and suitable for the purpose of classification under Regulation (EC) No.1272/2008. Based on the data, classification for acute toxicity is not warranted under Regulation (EC) No.1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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