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EC number: 421-820-9 | CAS number: 192268-65-8 CD 28-0132; IRGALUBE 232
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No reliable long-term toxicity test to fish are available. The available study was invalidated due to major flaws related to improper preparations of the test solutions.
However, as no toxicity was observed in the acute test long-term toxicity is not expected. Furthermore, in a bioaccumulation study fish were exposed to the uvcb substance (see IUCLID chapter 5.3.1). During 56 days of exposure in concentrations in the solubility range of triphenylthiophosphate no adverse effects were observed. In addition based on the substance properties (low water solubility, high adsorption potential and potential to be degraded in aquatic media), it can be concluded that the aquatic compartment is not the compartment of concern. The chemical safety assessment according to Annex 1 REACH does not indicate the need of further long-term ecotoxicological testing with aquatic organisms. Thus, a long-term test with fish does not need to be conducted in accordance with animal welfare reasons.
Key value for chemical safety assessment
Additional information
In a BCF study according to (GAKUSHUIN UNIVERSITY 1999) performed with the uvcb substance no adverse effects on fish were observed during 56 days of exposure in concentrations within the solubility range. The test concentrations of major constituents were verified in this test (See IUCLID chapter 5.3.1).
A test on early-life stage toxicity in fish according to OECD 210 was performed with the uvcb substance (Wildlife International 2003).
However, this study was invalidated due to major flaws related to improper preparations of the test solutions:
The available test was re-evaluated for validity and considering the latest recommendations of OECD No. 23: Guidance Document on the Aquatic Toxicity Testing of Difficult Substances and Mixtures it is concluded that the study suffers from major flaws which are related to improper preparation of the test solutions resulting in the presence of undissolved test substance in the test vessels. Since the test item (EC 421-820-9) is a multi-constituent substance, test solutions for aquatic ecotoxicity tests should be prepared as water accommodated fractions (WAF) as recommended by OECD No. 23: Guidance Document on the Aquatic Toxicity Testing of Difficult Substances and Mixtures (the available acute tests on fish, Daphnia and algae were prepared as WAF solutions resulting in NOECs > 100 mg/L). In the present test, the test solutions were prepared as dilutions of a solvent stock solution. Measured concentrations of the stock solutions were 91-97% of nominal but the measured test solutions were 39-128% of nominal. This level of variability in the analytical results is typically indicative of undissolved substance. The report also confirms the visual presence of undissolved substance in the diluters. The OECD No. 23 guidance document explicitly discourages both the use of solvents and serial dilution when testing multi-component substances. Therefore, the study is not reliable and was not further considered in the ecotoxicological risk assessment.
In accordance with column 2 of REACH Annex IX, long term toxicity test for fish is required (section 9.1.6). However, as no toxicity was observed in the acute test long-term toxicity is not expected. Furthermore, in a bioaccumulation study fish were exposed to the uvcb substance (see IUCLID chapter 5.3.1). During 56 days of exposure in concentrations in the solubility range no adverse effects were observed. In addition based on the constituents properties (low water solubility, high adsorption potential and potential to be degraded in aquatic media), it can be concluded that the aquatic compartment is not the compartment of concern.
However, to adequately address the substance toxic potential due to the low water solubility it was decided to repeat the chronic toxicity test on daphnids according to OECD guideline 211 under consideration of the OECD guidance document no 23 on difficult substances(BASF, 2015). No effects up to a loading rate of 5.5mg/L (WAF) were observed.Based on these data it can be expected that NOEC and EC10 for the major constituents (> 20%) is higher than the saturation concentration using a loading rate of 1mg/L (WAF).
The chemical safety assessment according to Annex 1 REACH does not indicate the need of further long-term ecotoxicological testing with aquatic organisms. Thus, a long-term test with fish does not need to be conducted in accordance with animal welfare reasons.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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