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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 227-534-9 | CAS number: 5873-54-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No long-term fish toxicity tests are available for the test substance. Due to the reactivity of the MDI substances with water and the extremely low water solubility it is considered appropriate to waive this study.
Key value for chemical safety assessment
Additional information
Due to the reactivity of the MDI substances with water, no fully adequate information from long-term aquatic fish toxicity studies of the MDI parent substances themselves is available. Also, these cannot be generated in a sound scientific manner. Any kind of media preparation for semi-static or flow-through exposures would involve hydrolysis, and thus the formation of degradation products. First and foremost, these are solid, inert and insoluble polyurea. These would be separated by centrifugation or filtration during WAF preparation and would therefore no longer be part of the final test medium. The same would apply to the evolving carbon dioxide, which would volatize from the testing medium. The only test compound that could potentially be remaining in the test solution would be the side-product MDA at a very low concentration. However, a long-term exposure to MDA would not occur under relevant environmental exposure scenarios, and the aquatic effects of MDA are known. The further common degradation product MDA has been adequately characterized with respect to its short- and long-term toxicity to aquatic organisms. The data generated confirms that representative MDI substances of the category do not cause adverse acute effects in fish at the loading limit concentration of 100 mg/L. Fish are not considered the most sensitive species. Hence, the entire category is considered not acute harmful towards this species. As fish are not considered to be the most sensitive species, there would be no information gain from a long-term aquatic study on the MDI category substances. In conclusion, there are no adequate chronic aquatic fish data on the MDI category substances (as such) available and cannot be meaningfully generated for the reasons mentioned. Additional testing is therefore not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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