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Diss Factsheets
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EC number: 201-222-2 | CAS number: 79-74-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well-performed non-GLP study. The study was identified as an inherent biodegradability test because the applied inoculum was pre-adapted to the test compound and the incubation exceeded the standard of 28 days in ready biodegradability tests.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- inoculum was pre-adapted to test compound
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: mixture of soil, raw sewage, and activated sludge
- Details on inoculum:
- - acclimation of inocolum:
* over 14-d period
* stepwise addition of test compound, no details available on added concentrations - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20.2 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: a minimal salts medium
- Test temperature: room temperature
- Aeration of dilution water: the mixture of inoculum and medium was aerated with 70 % oxigen in nitrogen before addition of the test compound
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: fluted 2-L Erlenmeyer flask
- Number of culture flasks/concentration: 3
- Method used to create aerobic conditions: no data
- Details of trap for CO2 and volatile organics if used: an open reservoir containing 10 mL of 0.15 N barium hydroxide is suspended via a glass tube inserted in a neoprene stopper.
- Barium hydroxide solutions were analyzed by titration with standard 0.1 N HCl to pH 8.5 using a Fisher Automatic Titrimeter II Titration System.
- Present Carbon (% C) was determined by means of a Perkin-Elmer Model 240 Elemental Analyzer.
SAMPLING
- Sampling frequency: no data
- Sampling method: Provisions for removal and addition of the barium hydroxide and for sampling the aqueous media are provided. Fresh barium hydroxide is added bac at each sampling point.
CONTROL AND BLANK SYSTEM
- control: assumed inoculum without test compound
- positive control: sodium citrate, 50.0 mg/L, in duplicate or triplicate
Flasks were sealed and agitated on a rotary shaker. - Reference substance:
- other: sodium citrate
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 1
- St. dev.:
- 1
- Sampling time:
- 38 d
- Remarks on result:
- other: Range: 0-3%
- Details on results:
- - results from triplicate flasks gave good agreement
- Results with reference substance:
- - 105 % after 38 days
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Reliable study (Klimisch 2) indicating that extensive ultimate biodegradation in the environment is unlikely to occur or that the rate of mineralization will be relatively slow.
Reference
Description of key information
The key result for biodegradation was derived from an inherent biodegradation study and indicates no biodegradation in water under the given test conditions.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Biodegradation of 2,5-bis(1,1-dimethylpropyl)benzene-1,4-diol was investigated in one study. This reliable study (Saeger, VW, MS-80-SS-42) indicated that the rate of mineralization can be expected to be relatively slow and that extensive ultimate biodegradation in the environment is unlikely to occur. In addition, results from the predictive models in BIOWIN indicate degradation can be assumed to happen very slow. Therefore, 2,5-bis(1,1-dimethylpropyl)benzene-1,4-diol should be considered not readily nor inherently biodegradable and further testing is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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