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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 205-355-7 | CAS number: 139-13-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guidelines: the comprehensive validation programme provided unequivocally identical results among the institutes
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Principles of method if other than guideline:
- largely acc. to OECD Guideline 471
- GLP compliance:
- yes
- Remarks:
- testing lab.
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 18662-53-8
- EC Number:
- 606-091-9
- Cas Number:
- 18662-53-8
- IUPAC Name:
- 18662-53-8
- Details on test material:
- Na3.NTA.H20, commercial
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: TA 98, 100, 1535, 1537, 1537, 1538; E. coli WP2 uvrA (trp+ reversion)
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat liver S-9 mix
- Test concentrations with justification for top dose:
- 3 - 3333 ug/plate (series of 7 sequential doses)
- Details on test system and experimental conditions:
- Liver S-9's were prepared from male Fischer 344 rats, B6C3F1 [C57B16 X C3H(He)] mice, and Syrian hamsters. The rats and mice were supplied to all laboratories by the NCI Carcinogenesis Testing Program and the hamsters were obtained by each laboratory from different suppliers. Livers were used from animals either without treatment or following treatment with Aroclor 1254 as described by Ames et al [1975]. The S-9 activation mixes were prepared daily, as needed.
The chernicals were from the Same batch used for the in vivo carcinogenicity bioassays conducted by the NCI/NTP. Each chemical was acquired by the NC.I Repository from the laboratory that had performed the in vivo bioassay and was reanalyzed for chemical purity (Midwest Research Institute, Kansas City, MO or Radian Corp., Austin, TX). Chemicals were not selected on the basis of the in vivo carcinogenicity test results because these results were not available, at that time, for all chemicals. Rather, an attempt was made to select those chemicals for which the experimental design (50 animalslgroup) was expected to provide conclusive carcinogenesis results.
The majority of chemicals were tested by the plate-incorporation procedure.
Each laboratory was asked to make its independent assessment of the dose ranges to be tested based on the solubility and toxicity of the test chemicals, but not to exceed 10.0 mg/plate. The doses were to be ordered in half-log increments. Chemicals were tested without activation, and with uninduced and Aroclor 1254-induced S-9's from rats, mice, and hamsters. All plates were prepared in triplicate, and concurrent positive and negative controls were run at all times.
Results and discussion
Test results
- Species / strain:
- other: TA 98, 100, 1535, 1537, 1537, 1538; E. coli WP2 uvrA (trp+ reversion)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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