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Diss Factsheets
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EC number: 205-355-7 | CAS number: 139-13-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
NTA is readily biodegradable.
See also section 3.1.2.1.1 and 3.1.2.1.2 of the EU RAR for trisodiumnitrilotriacetate (EINECS 225 -768 -6), final report, 2005, which also contains the relevant ecotox data for nitrilotriacetic acid. This report is attached in section 13:
A series of laboratory degradation tests is available for NTA (see Table 3.1). In most cases the
acid or the Na-salt was added and not the complexed NTA. However, the test media generally
contain, beside trace metals, calcium and/or magnesium ions in over-stoichiometric amounts, the
respective complexes are formed thus being the active test substances.
The test results indicate that the Ca/Mg complexes are readily removed. For instance, in a
Modified OECD Screening Test conducted according to OECD guideline 301 E, NTA was
found to be readily biodegradable. Meeting the 10 days time window criterion, the substance
(initial concentration 50 mg/l) was completely degraded within 14 days, as measured by DOC.
The inoculum used was taken from river water treatment plant. The lag phase until degradation
started was 5 days (BASF, 1983b).
Several bacteria strains capable of growth with NTA were isolated from wastewater, soil and
sediment. An aerobic Chelatobacter strain a monooxigenase is responsible for the initial
oxidation, leading to iminodiacetate (IDA) and glyoxylate. IDA is subsequently oxidised to
glycine and glyoxylate by a membrane-bound dehydrogenase. Denitrifying bacteria contain a
dehydrogenase/nitrate reductase complex, catalysing the formation of IDA, glyoxylate and nitrite
from NTA and nitrate (Egli, 1992, 1994).
The reaction pathway supports the result of the standard tests that NTA is completely
mineralised after primary degradation. Accumulation of a stable metabolite is not expected.
See further the in section 13 attached RAR
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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