Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-617-5 | CAS number: 7652-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 22, 2018 - Feburary 06, 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- flask method
Test material
- Reference substance name:
- 1,1'-(1,3-phenylenedicarbonyl)bis[2-methylaziridine]
- EC Number:
- 231-617-5
- EC Name:
- 1,1'-(1,3-phenylenedicarbonyl)bis[2-methylaziridine]
- Cas Number:
- 7652-64-4
- Molecular formula:
- C14H16N2O2
- IUPAC Name:
- 2-methyl-1-[3-(2-methylaziridine-1-carbonyl)benzoyl]aziridine
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Physical Description: Solid when frozen, viscous liquid at RT
- Source and lot/batch No.of test material: 3M; TN18-0007-1/1
- Expiration date of the lot/batch: 1/9/19
- Purity: 95.6%
- Storage condition of test material: Freezer
Results and discussion
Water solubility
- Key result
- Water solubility:
- 51.5 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 25 g/L
- Incubation duration:
- >= 24 - <= 161 h
- Temp.:
- 25 °C
- pH:
- >= 5 - <= 6
- Remarks on result:
- other:
- Remarks:
- % RSD = 27%. Temperature not reported, but assumed to be ambient room temperature.
- Details on results:
- The water saturation equilibrium (maximal water solubility) value for 1,1'-isophthaloylbis(2-methylaziridine) was achieved after 1 day of incubation and was maintained over 7 days. The average water solubility of 1,1'-isophthaloylbis(2-methylaziridine) at Time point 1, 2, 3, and 4 were 59.1 mg/L (25% RSD) , 54.7 mg/L (26% RSD), 42.8 mg/L (33% RSD) and 49.3 mg/L (22% RSD), respectively. The overall average was 51.5 mg/L (RSD = 27%).
A shift in the pH of water samples to slightly acidic (~ pH 5-6) was observed using pH paper.
Any other information on results incl. tables
Table 1. Water Saturation Concentrations (mg/L) of 1,1'-isophthaloylbis(2-methylaziridine)
Samples |
Time point 1 (24 hours) |
Time point 2 (48 hours) |
Time point 3 ( 137 hours) |
Time point 4 ( 161 hours) |
|
Sample 1, Rep 1 |
78.7 |
40.1 |
46.1 |
36.1 |
|
Sample 1, Rep 2 |
76.6 |
36.8 |
70.1 |
37.1 |
|
Sample 1 RPD% |
2.7% |
8.6% |
41% |
2.7% |
|
Sample 2, Rep 1 |
45.3 |
55.1 |
39.4 |
54.5 |
|
Sample 2, Rep 2 |
45.9 |
55.0 |
34.5 |
48.8 |
|
Sample 2 RPD% |
1.3% |
8.7% |
13% |
11% |
|
Sample 3, Rep 1 |
51.7 |
73.6 |
34.9 |
61.2 |
|
Sample 3, Rep 2 |
56.5 |
62.4 |
32.0 |
58.2 |
|
Sample 3 RPD% |
8.9% |
16% |
8.7% |
5.0% |
|
|
|
|
|
|
|
Intra-day Average (mg/L) |
59.1 |
54.7 |
42.8 |
49.3 |
|
Intra-day RSD% |
25% |
26% |
33% |
22% |
|
Overall Average (mg/L) |
|
|
|
51.1 |
|
Overall RSD % |
|
|
|
27% |
Applicant's summary and conclusion
- Conclusions:
- The water solubility of 1,1'-isophthaloylbis(2-methylaziridine) was determined to be 51.5 mg/L (± 27%RSD) at ambient temperature.
- Executive summary:
The water solubility of 1,1'-isophthaloylbis(2-methylaziridine) was determined according to the U.S. EPA guidance document OPPTS 830.7840 “Water Solubility: Column Elution Method; Shake Flask Method”.
Triplicate samples were prepared by adding 0.250 g of test substance to the bottom of a test vial, then 10 mL of Milli-Q™ water was added to each vial. Samples were then incubated in an orbital shaker at approximately 30 °C and at a setting of 100 revolutions per minute (RPM) for four incubation time points (24, 48, 137 and 161 hours). At the end of each time point, the vials were removed from the incubator, centrifuged, and then placed at room temperature for approximately 24 hours to equilibrate the sample temperature. The vials were centrifuged again. Duplicate aliquots of aqueous phase were removed, diluted 10,000-fold in acetonitrile, and analyzed via LC/MS/MS.
The water saturation equilibrium (maximal water solubility) value for 1,1'-isophthaloylbis(2-methylaziridine) was achieved after 1 day of incubation and was maintained over 7 days. The average water solubility of 1,1'-isophthaloylbis(2-methylaziridine) at Time point 1, 2, 3, and 4 were 59.1 mg/L (25% RSD) , 54.7 mg/L (26% RSD), 42.8 mg/L (33% RSD) and 49.3 mg/L (22% RSD), respectively. The overall average was 51.5 mg/L (RSD = 27%).
This is a guideline study, however, not conducted under GLP compliance. The test results had high variation for intra-sample and intra-day measurements. Therefore, it is considered reliable with restriction (Klimisch 2) and a key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)