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Diss Factsheets
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EC number: 217-615-7 | CAS number: 1910-42-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 1985 to June 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- yes
- Remarks:
- Tested at pH 5, 7 and 9 (should be 4,7 and 9 according to the guideline) and at temperatures of 25 and 40°C (should be 50°C according to the guideline)
- GLP compliance:
- yes
- Radiolabelling:
- yes
- Remarks:
- 14C
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 0, 2, 8, 16 and 30 days
- Sampling method: Duplicate flasks were taken for analysis from each set of buffer solutions at both temperatures.
- Sampling intervals/times for pH measurements: The pH values of the buffer solutions were measured at ambient temperature at time zero and after 30 days incubation and at 40°C.
- Sample storage conditions before analysis: The samples were stored at -20°C prior to analysis. - Buffers:
- - pH 5: 0.1 M potassium hydrogen phthalate and 0.05 M sodium hydroxide in a 1:1 ratio
- pH 7: 0.071 M potassium dihydrogen orthophosphate and 0.05 M disodium hydrogen phosphate in a 1:1 ratio
- pH 9: 0.1 M potassium chloride in 0.1 M boric acid and 0.05 M sodium hydroxide in a 1:1 ratio
- Measured pH day 0: 5.00, 6.87 and 9.07
- Measured pH day 30: 5.01, 6.86 and 9.08
- pH at 40 °C: 5.09, 6.81 and 8.95 - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: 50 mL quickfit stoppered conical flasks were incubated in a shaking water bath.
- Sterilisation method: To ensure sterile conditions for the hydrolysis, buffer solutions and all the glassware used was placed in an autoclave overnight (Maximum temperature 121°C at 15 psi pressure). Substance stock solutions were sterilized by passing through a bacteriological aqueous filter (0.22μm). All transfer of solutions was carried out in a laminar flow hood.
- Measures taken to avoid photolytic effects: The water baths were tightly covered to exclude light.
TEST MEDIUM
- Volume used: 0.7 mL of radiolabelled stock solution, 2.55 mL of non labelled stock solution and buffer to give a final volume of 30mL. - Duration:
- 30 d
- pH:
- 5
- Temp.:
- 25 °C
- Initial conc. measured:
- >= 89.3 - <= 90.2 mg/L
- Duration:
- 30 d
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- >= 95.9 - <= 98.1 mg/L
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- >= 82.1 - <= 85.6 mg/L
- Duration:
- 30 d
- pH:
- 5
- Temp.:
- 40 °C
- Initial conc. measured:
- >= 92.7 - <= 94.7 mg/L
- Duration:
- 30 d
- pH:
- 7
- Temp.:
- 40 °C
- Initial conc. measured:
- >= 94.2 - <= 95.3 mg/L
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 40 °C
- Initial conc. measured:
- >= 79.4 - <= 90.5 mg/L
- Number of replicates:
- Duplicates
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- - Recovery of radioactivity: over the incubation period, at both temperatures and at all pH values there was no significant loss of radioactivity.
- Chromatographic analysis: samples taken after 2, 8, 16 and 30 days incubation showed that no significant breakdown had occurred.
- Details are provided in the 'any other information on results incl. tables' section - % Recovery:
- > 100
- pH:
- 5
- Temp.:
- 25 °C
- Duration:
- 30 d
- % Recovery:
- >= 98
- pH:
- 5
- Temp.:
- 40 °C
- Duration:
- 30 d
- % Recovery:
- >= 97
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 30 d
- % Recovery:
- >= 96
- pH:
- 7
- Temp.:
- 40 °C
- Duration:
- 30 d
- % Recovery:
- >= 87 - <= 99
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 30 d
- % Recovery:
- > 100
- pH:
- 9
- Temp.:
- 40 °C
- Duration:
- 30 d
- Key result
- pH:
- 9
- Temp.:
- 40 °C
- Remarks on result:
- not determinable
- Remarks:
- Substance is hydrolytically stable under the tested conditions
- Key result
- pH:
- 7
- Temp.:
- 40 °C
- Remarks on result:
- not determinable
- Remarks:
- Substance is hydrolytically stable under the tested conditions
- Key result
- pH:
- 5
- Temp.:
- 40 °C
- Remarks on result:
- not determinable
- Remarks:
- Substance is hydrolytically stable under the tested conditions
- pH:
- 9
- Temp.:
- 25 °C
- Remarks on result:
- not determinable
- Remarks:
- Substance is hydrolytically stable under the tested conditions
- pH:
- 7
- Temp.:
- 25 °C
- Remarks on result:
- not determinable
- Remarks:
- Substance is hydrolytically stable under the tested conditions
- pH:
- 5
- Temp.:
- 25 °C
- Remarks on result:
- not determinable
- Remarks:
- Substance is hydrolytically stable under the tested conditions
- Details on results:
- TEST CONDITIONS
At pH 5, 7 and 9:
- Over the incubation period, at both temperatures and at all pH values there was no significant loss of radioactivity.
- Chromatographic analysis (TLC and linear scanning of the chromatoplates) of the samples taken after 2, 8, 16 and 30 days incubation showed that no significant breakdown of the substance had occurred.
- Detailed results of the chromatographic analysis of the 30 day samples are provided in the 'any other information on results incl. tables' section. - Validity criteria fulfilled:
- yes
- Conclusions:
- The results from this study show that the test substance is stable to hydrolysis at temperatures up to 40°C at pH 5 to 9 for 30 days.
- Executive summary:
The hydrolysis potential of the 14C radiolabelled test item was investigated in a study similar to OECD TG 111 and in compliance with GLP criteria. This study was performed at 25 and 40 °C for 30 days at pH values of 5, 7 and 9 in duplicate. All incubations were conducted under sterile and dark conditions. The degradation of the parent compound over a period of time was measured using both thin layer chromatography and high performance liquid chromatograph and recovery of radioactive content was determined with liquid scintillation counting. TLC and scintillation counting were performed after 2, 8, 16 and 30 days. Since no significant breakdown was observed detailed chromatographic analysis of the 30 day samples is only reported. The results show that over the incubation period, at both temperatures and at all pH values there was no significant loss of radioactivity. In addition, chromatographic analysis showed that no significant breakdown had occurred during the 30 day period. Therefore, the substance is considered to be hydrolytically stable.
Reference
Table: Mean percentage of radioactivity present as paraquat after day 0 and day 30
Sample interval |
Temperature (°C) |
Sample |
pH 5 |
pH 7 |
pH 9 |
Day 0 |
25 |
A |
97.5 |
97.8 |
95.5 |
Day 0 |
25 |
B |
94.7 |
96.0 |
96.9 |
Day 0 |
40 |
A |
95.3 |
96.6 |
96.8 |
Day 0 |
40 |
B |
97.9 |
95.6 |
96.4 |
Day 30 |
25 |
A |
96.3 |
94.7 |
97.5 |
Day 30 |
25 |
B |
94.8 |
94.4 |
96.9 |
Day 30 |
40 |
A |
96.2 |
97.2 |
93.0 |
Day 30 |
40 |
B |
90.9 |
95.5 |
94.7 |
Description of key information
The test substance is hydrolytically stable at pH values of 5, 7 and 9 at a temperature of 25 and 45 °C, OECD TG 111, Upton, 1985
Key value for chemical safety assessment
Additional information
Method |
Guideline / GLP |
Comment |
Reference |
||
Temperature |
pH |
Duration |
|||
25 °C |
5 |
30 d |
OECD TG 111 |
The test item is hydrolytically stable at pH values of 5, 7 and 9 at temperature of 25 and 45 °C |
Upton, 1985 |
25 °C |
7 |
30 d |
|||
25 °C |
9 |
30 d |
|||
40 °C |
5 |
30 d |
|||
40 °C |
7 |
30 d |
|||
40 °C |
9 |
30 d |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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