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Diss Factsheets
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EC number: 201-297-1 | CAS number: 80-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study well documented, meets generally accepted scientific principles, acceptable for assessment. With regard to carcinogenicity testing, the number of animals used in this test is below current guideline requirements. The power of this study and the negative finding have to be placed into perspective with the other three negative in vivo studies, the absence of genotoxicity and the lack of positive evidence in the cancer mortality studies on MMA.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the Chronic Oral Toxicity of Monomeric Ethyl Acrylate and Methyl Methacrylate.
- Author:
- Borzelleca JF, Larson PS, Hennigar GR, Huf EG, Crawford EM, Blackwell, Smith R
- Year:
- 1 964
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 6: 29-36
Materials and methods
- Principles of method if other than guideline:
- other: not applicable
- GLP compliance:
- no
Test material
- Details on test material:
- Methylmethacrylate; purity not reported. The undiluted stock was inhibited from polymerization with 10 ppm of monomethyl ether of t-butylhydroquinone.
Constituent 1
Test animals
- Species:
- dog
- Strain:
- other: purebred Beagle dog
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: oral, dietary equivalents as Gelatine capsule containing MMA solution in corn oil
- Vehicle:
- corn oil
- Details on exposure:
- Methyl methacrylate was dissolved in corn oil and administered to beagle dogs in gelatin capsules at doses equivalent to that achieved by dietary concentrations of 0, 100, 100 or 1000 - 1500 ppm on a daily basis.
- Duration of treatment / exposure:
- 104 weeks (2 years)
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10, 100 and 1000 - 1500 ppm
In the high-dose group, the initial concentration administered was 1000 ppm and was then increased to 1200 ppm at week 5, to 1400 ppm at week 7 and to 1500 ppm at week 9, continuing through the end of the study. The animals were individually housed and provided feed ad libitum.
- No. of animals per sex per dose:
- Two males and two females were tested at each dose.
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Post-exposure period: Not applicable
Examinations
- Observations and examinations performed and frequency:
- Body weights were measured prior to study initiation, and at weeks 13, 26, 39, 52, 65, 78, 91 and 104. Hematological measurements, including hematocrit, hemoglobin, total white and differential white cell counts, were obtained from each animal prior to study initiation, and at 2, 4 and 13 weeks and at three month intervals thereafter. Urine samples were collected to evaluate urinary concentrations of reducing substances and proteins at the same time periods.
- Sacrifice and pathology:
- At sacrifice organ to bodyweight ratios were determined for the heart, spleen, kidney, liver and testes. Select tissues collected and preserved from all survivors and decedents included: heart, lung, liver, kidney, urinary bladder, spleen, gastroenteric, skeletal muscle, bone marrow, skin, brain, thyroid, adrenal, pancreas, pituitary and gonads. Histopathological examinations were made on all tissues from each dog.
Results and discussion
Results of examinations
- Body weight and weight changes:
- effects observed, treatment-related
- Haematological findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- no effects observed
- Details on results:
- A decrease in body weight gain was observed in the dogs administered methyl methacrylate at a concentration of 1000 - 1500 ppm. Hematological values and urine concentrations of reducing substances and proteins were within the normal ranges for all groups tested. Organ to body weight ratios were similar between the treated animals and those of the control animals, except a statistically significant decrease in spleen ratios was observed in dogs receiving 100 ppm methyl methacrylate. The biological significance of this finding was not apparent. No abnormal histopathological findings were noted.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 100 ppm
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The authors did not state a NOAEL but it is considered to be 100 ppm.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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