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Diss Factsheets
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EC number: 201-159-0 | CAS number: 78-93-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- April - August 1942
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: relatively old publication with limited information
Data source
Reference
- Reference Type:
- publication
- Title:
- Sensory response to certain industrial solvent vapors
- Author:
- Nelson KW, Ege JF, Ross MJ, Woodman LE & Silverman L
- Year:
- 1 943
- Bibliographic source:
- Journal of Industrial Hygiene and Toxicology 25: 282-285
Materials and methods
- Type of study / information:
- Inhalation experiment in human subjects
- Principles of method if other than guideline:
- The object of the experiment was to evaluate on humans the effects of some common solvent vapour concentrations. It was thought that the information gained could then be used as a valuable supplemental to present industrial experience. The solvents studied included hydrocarbons, alcohols, ketones, esters and ethers. The ketone group included butanone.
- GLP compliance:
- no
Test material
- Reference substance name:
- Butanone
- EC Number:
- 201-159-0
- EC Name:
- Butanone
- Cas Number:
- 78-93-3
- Molecular formula:
- C4H8O
- IUPAC Name:
- butan-2-one
- Details on test material:
- - Name of test material (as cited in study report): Butanone
Constituent 1
Method
- Details on exposure:
- The experiment consisted of the exposure in a 1200 cubic foot gas cabinet of an average number of 10 people of both sexes to a given concentration of solvent vapour for a period of 3 to 5 minutes. After the exposure, each individual classified the effect of the vapour on the eyes, nose and throat. The classifications were: no reaction, slightly irritating and very irritating. The odour was reported as absent, definite, moderate, strong or overpowering. Finally all persons were asked if they believed they could work in the atmosphere for an 8 hour day. The subjects, except the experimenters were not told of the actual concentrations and whether or not the exposures to any one solvent were in order of increasing or decreasing concentration
Results and discussion
- Results:
- Butanone produced slight nose and throat irritation at 100 ppm. Mild eye irritation appeared in some subjects at 200 ppm. 300 ppm was conclusively rejected. A practical limit of 200 ppm is indicated (see table 1)
Any other information on results incl. tables
Table 1: Sensory limits obtained for butanone
Solvent |
Highest concentration which majority of subjects estimated satisfactory for 8-hour exposure ppm |
Concentration or vapour which irritated majority of subjects |
||
Eyes ppm |
Nose ppm |
Throat ppm |
||
Butanone |
200 |
350 |
350 |
350 |
Applicant's summary and conclusion
- Conclusions:
- A sensory limit of 200 ppm of butanone is considered to be acceptable in providing comfortable working conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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