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EC number: 231-977-3 | CAS number: 7783-06-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
There is a combined systemic- and reproduction toxicity study according to OECD 421 with H2S availiable. In this study not only the toxicity to reproduction was investigated but also the systemic toxicity. Specific attention was put on the histopathology of the nose and its epitheleum as first target for a respiratory irritation.
In contrast to all the other specific investigations on respiratory tract irritation in literature an accepted guideline-conform procedure for the evaluation of respiratory tract irritation has been used. In this GLP study Dorman et al. (2000) examined the effects of an inhalation exposure to H2S. According to OECD 421 groups of 12 male and 12 female Sprague-Dawley rats were exposed to hydrogen sulfide at 0, 10, 30, or 80 ppm 6 h/day, 7 days/week for 2 weeks before breeding. Exposures continued during a 2-week mating period and then on GD 0-19. Exposure of the dams and pups (eight rats per litter after culling) resumed from PND 5 to PND 18. Adult male rats were exposed on 70 consecutive days.
The extensive histopathologic examination of the nose revealed a significant increase in nasal lesions of the olfactory mucosa. A markedly increased incidence of olfactory neuron loss and basal cell hyperplasia was found following exposure to 30 and 80 ppm H2S. The no observed adverse effect level for these respiratory lesions was 10 ppm.
All the other studies reported in literature were not performed according to a guideline and used much shorter exposition times per day as the study of Dorman et al. (2000). Therefore their results are not comparable to the guideline study and these studies are judged as "not reliable" or as "not assignable" and the results of these studies are not used for the evaluation of the respiratory tract irritation of H2S.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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