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Diss Factsheets
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EC number: 247-873-6 | CAS number: 26650-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1961
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted non-GLP, however there was an acceptable documented study report which meets basic scientific principles. It is therefore considered to be relable. As the subcutaneous route is less relevant, the study is also not adequate for classification.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 401
- Deviations:
- yes
- Remarks:
- subcutaenous route; observation 24 hours.
- Principles of method if other than guideline:
- Single s.c. application to mice and calculation of 24 hour LD50
Study performance before implementation of corresponding international guidelines - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Disodium 4-[2-[(1-oxoundec-10-enyl)amino]ethyl] 2-sulphonatosuccinate
- EC Number:
- 247-873-6
- EC Name:
- Disodium 4-[2-[(1-oxoundec-10-enyl)amino]ethyl] 2-sulphonatosuccinate
- Cas Number:
- 26650-05-5
- Molecular formula:
- C17H29NO8S.2Na
- IUPAC Name:
- disodium 4-[2-[(1-oxoundec-10-enyl)amino]ethyl] 2-sulphonatosuccinate
- Details on test material:
- - Name of test material (as cited in study report): SBU-185
-Substance type: Sulfosuccinate (tensio-active)
- Analytical purity: At least 49%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no further data
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- water
- Doses:
- 0.02, 0.2, 1.0, 2.0, 4.0 and 8.0 g/kg bw
- No. of animals per sex per dose:
- 3 to 10
- Control animals:
- no
- Details on study design:
- 3, 4, 5, 10, 10 and 5 mice were subcutaneously dosed with 0.02, 0.2, 1.0, 2.0, 4.0 and 8.0 g/kg bw , respectively.
- Duration of observation period following administration: 24 hours
- Necropsy of survivors performed: no
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 300 mg/kg bw
- Based on:
- test mat.
- Remarks:
- as delivered by the sponsor
- Remarks on result:
- other: Observation period: 24 hours
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 617 mg/kg bw
- Based on:
- other: Recalculated LD50 referring to solid content of the test material (according to producers information): 49 % in minimum
- Mortality:
- Up to and including a dose of 1000 mg/kg bw all animals survived. In the dose groups of 2000, 4000 and 8000 mg/kg bw 3/10, 6/10 and 5/5 animals died, respectively. (See Table 1)
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
Any other information on results incl. tables
Table 1. Mortality after single subcutaneous dose
Dose (mg/mouse) |
Dose (mg/kg bw) |
Number of dosed animals |
Mortality (%) |
0.4 |
20 |
3 |
0 |
4.0 |
200 |
4 |
0 |
20.0 |
1000 |
5 |
0 |
40.0 |
2000 |
10 |
30 |
80.0 |
4000 |
10 |
60 |
160.0 |
8000 |
5 |
100 |
LD50 as reported by the study authors: approximately 3300 mg/kg bw.
Applicant's summary and conclusion
- Conclusions:
- The subcutane LD50 of SBU-185 was > 1617 mg act.ingr./kg bw.
- Executive summary:
In an acute toxicity study groups of mice were given a single subcutaneous dose of SBU-185 (at least 49% act. ingr.) at doses of 20, 200, 1000, 2000, 4000 and 8000 g/kg bw of the test material and observed for 24 hours.
Up to and including a dose of 1000 mg/kg bw all animals survived. In the dose groups of 2000, 4000 and 8000 mg/kg bw 3/10, 6/10 and 5/5 animals died, respectively.
Subcutaneous LD50 : approximately 3300 mg/kg bw.
LD50 value determined refers to the test substance as delivered by the sponsor.
Subcutaneous LD50 : approximately 1617 mg/kg bw in minimum (referring to solid content).
Solid content of test item according to producers information: 49 % in minimum.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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