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Diss Factsheets
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EC number: 247-873-6 | CAS number: 26650-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1964-10-24 to 1965-03-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted non-GLP, however it was performed according to state of the art methods with an acceptable, well documented study report which meets basic scientific principles. It is therefore considered adequate, reliable and relevant.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Appraisal of the safety of chemicals in foods, drugs and cosmetics of the association of food and drug officials of the United States 1959
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no necropsy data for survivors
- GLP compliance:
- no
- Remarks:
- study performance before implementation of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium 4-[2-[(1-oxoundec-10-enyl)amino]ethyl] 2-sulphonatosuccinate
- EC Number:
- 247-873-6
- EC Name:
- Disodium 4-[2-[(1-oxoundec-10-enyl)amino]ethyl] 2-sulphonatosuccinate
- Cas Number:
- 26650-05-5
- Molecular formula:
- C17H29NO8S.2Na
- IUPAC Name:
- disodium 4-[2-[(1-oxoundec-10-enyl)amino]ethyl] 2-sulphonatosuccinate
- Details on test material:
- - Name of test material (as cited in study report): SBU 185 (50 % aqueous solution)
- Substance type: Sulfosuccinate (tensio-active)
- Physical state: Aqueous solution
- Analytical purity: Not provided
- Impurities (identity and concentrations): Not provided
- Lot/batch No.: Not provided
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided
- Storage condition of test material: Not provided
- Other: the registered trade mark for SBU 185 in Germany is Steinazid SBU 185, in Great Britain: Loramine SBU 185
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: young adults
- Weight at study initiation: no data
- Fasting period before study: overnight
- Housing: no data
- Diet (e.g. ad libitum): ad libitum, standardised laboratory died
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 1.99, 2.51, 6.31, 8.00 and 10.00 g/kg bw
The test material was applied in the original state (aqueous solution, 50 %), as delivered by the sponsor. - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- Healthy adult albino rats were fasted overnight prior to dosage. Groups of 10 rats each were balanced with respect to weight and sex distribution. Alldoses were given by stomach tube. After dosing, the rats were returned to their individual cages. Water and later feed cups containing their regular food was restored.
After preliminary range finding experiments the dose levels for SBU 185 are set as follows: 1.99 g/kg bw; 2.51 g/kg bw; 6.31 g/kg bw; 8.00 g/kg bw and 10.00 g/kg bw. It was impossible to give higher doses than 10 g/kg by stomach tube as the material had to be used in 50% solution and because in higher concentrations it is too viscous. The rats were observed frequently during the dosage days, mortality records being made at daily intervals for a period of two weeks. Records were kept of body weight and of any departure from normal health, behavior and appearance.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks:
- as delivered by the sponsor
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 450 mg/kg bw
- Based on:
- other: Recalculated LD50 referring to solid content of the test material (according to producers information): 24.5 % in minimum
- Mortality:
- In the dose groups 1.99, 2.51, 6.31, 8.00 and 10.00 g/kg bw 10, 0, 0, 10 and 20 %, respectively. Animals were found death on the first or second day after application.
- Clinical signs:
- none
- Body weight:
- no dose related effects
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- On the basis of the results obtained after a single oral administration, the oral LD50 of the test article SBU 185 (50%) was determined to be > 10000 mg/kg bw ; recalculated LD50 referring to solid content: > 2450 mg/kg bw in minimum. No significant clinical signs or effects on body weight were observed. Classification for acute oral toxicity Caregory V is justified for SBU 185 according to OECD GHS (2nd rev. edition, UN, 2007).
- Executive summary:
In an acute oral toxicity study groups of fasted male and female young adult albino rats were given a single oral dose os SBU 185 (50%) at doses of 1990, 2510, 6310, 8000 and 10000 mg/kg bw and observed for 14 days.
In the dose groups 1990, 2510, 6310, 8000 and 10000 mg/kg bw 10, 0, 0 ,10 and 20% of animals died , respectively. Animals were found death on the first or second day after application. No clinical signs or effects on body weight were observed.
Oral LD50 males/females >10000 mg/kg bw
The LD50 determined refers to the test material as specified above (50%).
LD50 (14 days) referring to solid content: > 2450 mg/kg bw in minimum.
Solid content of SBU 185 50% according to producers information: minimum 24.5%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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