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Diss Factsheets
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EC number: 205-711-1 | CAS number: 148-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Skin sensitisation, patch test (key, RL2): sensitising
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Sensitisation
No skin sensitisation studies in animals are available to evaluate the skin sensitizing properties of quinolin-8-ol (CAS 148-24-3). However, relevant information in humans is available that allow a final assessment of skin sensitising properties induced by quinolin-8-ol.
Skin sensitising properties of quinolin-8-ol (CAS 148-24-3) were determined in a human Patch test by topical application of the test substance (Pevny and Schellenberger, 1971). Three Patch tests were conducted with 100 or 127 patients. A positive sensitisation response was observed in all three tests. The indices of sensitivity (percentage of positive responses) were 4.7%, 8% and 6% in all 3 studies, respectively. Thus, quinolin-8-ol is considered to be an allergen in humans.
Furthermore, patients showed signs of contact allergy to quinolin-8-ol and to 8-hydroxyquinoline sulphate during dermatological therapies. In detail, in an epidermal test series for the determination of contact eczema caused by drugs within a period of six years, hypersensitivity to 8-hydroxyquinoline was observed in 3/450 patients indicating that quinolin-8-ol is a weak contact allergen. Furthermore, 8-hydroxyquinoline sulphate showed a positive response in one subject at concentrations above 0.01% and was considered as strong sensitiser (as cited in RAC opinion (Rothe, 1978; Metzner, 1987).
Overall conclusion
Based on the available data, human data provide evidence that quinolin-8-ol exhibits skin sensitisng properties by skin contact in a substantial number of people. Thus, quinolin-8-ol is considered as skin sensitizer. Due to limited information, sub-categorisation according to CLP criteria is not possible.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitization induced by quinolin-8-ol (CAS 148 -24 -3) meet the criteria for classification as Skin sens 1, H317 according to Regulation (EC) 1272/2008. Due to limited information, sub-categorisation according to CLP criteria is not possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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