Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-711-1 | CAS number: 148-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Probelte S.A., Manufacturer batch number: 7003, Probelte batch number: 312432
- Sort of product: Solid crystalline
- Expiration date of the lot/batch: Not specified
- Purity test date: 99.9% p/p
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Maintain at room temperature
- Stability under testing conditions - Radiolabelling:
- yes
- Analytical monitoring:
- yes
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.271 g/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.271 g/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.271 g/L
- Preliminary study:
- Three samples were prepared to a concentration equal to half the saturation concentration (0.26-0.27 g/L) and dissolved in the buffered solutions at pH 4, 7 and 9. A known quantity of 8-HQ technical product has been weighed to contain 0.0265g in 100 ml the buffered solution. After these 3 samples are prepared, they are submitted at 50C for a period between 2,4hours and 5 days. Some aliquots are periodically taken and analyzed, quantifying the content of 8.HQ by HPLC.
- Transformation products:
- not specified
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.59 d-1
- DT50:
- > 1 yr
- Type:
- not specified
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 8.61 d-1
- DT50:
- > 1 yr
- Type:
- not specified
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 54.3 d-1
- DT50:
- > 1 yr
- Type:
- not specified
- Validity criteria fulfilled:
- yes
- Conclusions:
- The half-life for 8-HQ dissolved in buffered solution at pH 4, 7 and 9 is higher thatn 1 year in the environmentak relevant conditions (25 C)
- Executive summary:
The stability of 8-hydroxyquinoline to hydrolysis at pH 4, 7 and 9 was tested on a preliminary study at 50ºC (García, A. 2004). The study was conducted according to the EEC C.7 guideline, "abiotic degradation: hydrolysis as a function of pH". The concentrations of test item were quantified via HPLC and external standards.
In the preliminary test, 8-HQ samples were dissolved in buffered solutions of different pH values, and the they were put at 50C with a lack of light to observe the pH and temperature effects of the active ingredient on hydrolysis. In this way, no hydrolysis of the active ingredient was observed in the sample at Ph 4, In the sample of pH 7, a hydrolysis lower than 10% was observed after 5 days at 50C with a lack of light. In the sample at Ph9, when sample was dissolved. In the sample at pH 9, when the sample was dissolved with the lack of light and presence of oxygen, a decreased of concentration was observed in the assay conditions of the preliminary test. Due to the decreased of the concentration that the active ingredient shows at a basic Ph, the preliminary test was carried out in conditions of nitrogen atmosphere, with a lack of light and at 50C, using two different buffered solutions at pH 9. Hydrolysis lower than 10% has been obtained in both cases under mentioned conditions after 5 days.
Reference
Description of key information
The stability of 8-hydroxyquinoline to hydrolysis at pH 4, 7 and 9 was tested on a preliminary study at 50ºC (García, A., 2004). The study was conducted according to the EEC C.7 guideline, "abiotic degradation: hydrolysis as a function of pH". The concentrations of test item were quantified via HPLC and external standards. The results indicate that 8-HQ was stable to hydrolysis at pH 4 and 7 and 50ºC after 5 days (<10% degradation). At pH 9 it was also stable in the absence of oxygen (< 10% degradation). Hence, the half-life for 8-HQ dissolved in buffered solution at pH 4, 7 and 9 is higher thatn 1 year in the environmental relevant conditions (25 degrees Celsius).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)