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EC number: 203-310-6 | CAS number: 105-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: irritating
Eye irritation: irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Principles of method if other than guideline:
- Primary skin irritation was recorded in a 10-grade ordinal series and is based upon the severest reaction that developed on the clipped skin of each 5 albino rabbits within 24 hours of the uncovered application of undiluted sample or of solutions in water, propylene glycol, or acetone.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Vehicle:
- other: undiluted sample or solutions in water, propylene glycol or acetone
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 mL (undiluted)
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- no data
- Number of animals:
- 5 animals
- Details on study design:
- SCORING SYSTEM:
- Method of calculation: Primary skin irritation was recorded in a 10-grade ordinal series and is based upon the severest reaction that developed on the clipped skin; Grade 1: indicated no irritation, Grade 2: least visible capillary injection from the undiluted chemical; Grade 3: strong capillary injection; grade 4: slight erythema; Grade 5: strong erythema, edema or slight necrosis; Grade 6: indicated necrosis when undiluted, Grade 10: indicated necrosis from a 0.01% solution; - Remarks on result:
- other:
- Remarks:
- The primary skin irritation was graded as 2.
- Irritant / corrosive response data:
- The primary skin irritation was graded as 2.
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Based on the Harmonised classificatation Annesx VI of Regulation (EC) No 1272/2008 (CLP Regulation) the substance is classified as skin irritating cat. 2 (H315).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Principles of method if other than guideline:
- Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- other: undiluted sample or solutions in water or propylene glycol
- Amount / concentration applied:
- several amounts starting at 500μL (based on Carpenter et al., 1946, Chemical Burns of the Rabbit Cornea. Am.J.Opthal. 29:1363)
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data (usually 5)
- Details on study design:
- SCORING SYSTEM: Grade 1 indicates at most a very small area of necrosis resulting from 0.5 ml of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn f rom 0.005 ml, and Grade 10 indicates a severe burn from 0.5 ml of a 1% solution in water or propyene glycol.
- Remarks on result:
- other: The primary eye irritation was graded as 2.
- Irritant / corrosive response data:
- The primary eye irritation was graded as 2. This corresponds to 0.5 ml of undiluted test substance resulting in a score between 1 and 5.
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Based on the Harmonised classificatation Annesx VI of Regulation (EC) No 1272/2008 (CLP Regulation) the substance is classified as irritating to eyes cat. 2 (H319).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The available studies for skin and eye irritation are not suitable to draw a final conclusion concerning C&L, due to missing detailed information. However, the results provide an indication of an slight skin and eye irritating potential, which support the classification according to Regulation (EC) No 1272/2008 as skin and eye irritanting.
Primary skin irritation was recorded in a 10-grade ordinal series and is based upon the severest reaction that devoleoped on the clipped skin of each 5 albino rabbits within 24 hours of the unvovered application of undiluted sample or of solutions in water, propylene glycol or acetone. The primary skin irritaion grade was 2, most propably resulting from capillary injection of the undiluted chemical (Smyth, 1949).
Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemicals. The primary eye irritation was graded as 2. This corresponds to 0.5 ml of undiluted test substance resulting in a score between 1 and 5 (Smyth, 1949).
Justification for classification or non-classification
According to Regulation (EC) No 1272/2008 Annex VI Table 3.1, 1,1-diethoxyethane is classified as skin irritating cat 2 (H315) and eye irritating cat 2 (H319), respectively.
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