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Diss Factsheets
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EC number: 203-310-6 | CAS number: 105-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
acute oral:
rat (male): LD50 = 4.57 g/kg bw (ca. 4570 mg/kg bw; Smyth, H.F. et al., 1949)
acute inhalation:
rat, IRT: 2/6 animals died at 4000 ppm (19613.27 mg/m³) (Smyth, H.F. et al., 1949)
- acute dermal:
rabbits (male): LD50 = 10.0 ml/kg bw (ca. 8276 mg/kg bw; Smyth, H.F. et al., 1949)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- The single oral toxicity was determined by gastric intubation of groups of 5 non-fastened, male Carworth Wistar rats.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Carworth Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: reared in the oqn colony
- Age at study initiation: 4-5 weeks
- Weight at study initiation: 90 - 120 g
- Fasting period before study: animals were not fasted
- Diet (e.g. ad libitum): Rockland rat diet - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- no data, the dosages were arranged in an logarithmic series differing by a factor of 5
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 570 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 4 570 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- abstract
- Principles of method if other than guideline:
- Concentrated vapor inhalation was performed exposing groups of 6 male or female albino rats to a flowing stream of vapor-loaded air. The vapor-air mixture was generated by passing 2.5 l/min of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 ml of the test substance in a gaswashing bottle. Inhalations were continued for 8 hours in a logarithmic series. The observation period lasted 14 days.
- GLP compliance:
- no
- Test type:
- other: inhalation risk test
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: 2.5 l/min
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 4000 ppm (19613,27 mg/m³)
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Exp. duration:
- 4 h
- Remarks on result:
- other: 2/6 animals died at 4000 ppm (19613,27 mg/m³)
- Mortality:
- 2/6 animals died during 14 days.
- Clinical signs:
- other: no data
- Body weight:
- no data
- Gross pathology:
- no data
Reference
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- The LD50 was determined by a method closely akin to the one-day cuff method of Draize et al. (1944) using groups of 4 male albino New Zealand rabbits. The fur was removed by clipping and the dose was retained beneath an impervious plastic film (i.e. occlusive). The animals were immobilized/exposed for 24 hours. Afterwards, the film was removed and the animals were observed for 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg - Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 4 male animals
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- LD50 value and its confidence interval was estimated by the method of Thompson (1947).
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 8 276 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value:10 ml/kg = 8276 mg/kg bw (calculatd by the density of 0.8276 g/l)
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 8 276 mg/kg bw
Additional information
In a reliable publication of Smyth, H.F. et al (1949) the acute oral toxicity of the test substance was determined by gastric intubation of groups of 5 non-fastened, male Carworth Wistar rats. The LD50 was determined as 4.57 g/kg bw (ca. 4570 mg/kg bw).
In an Inhalation Risk Test performed by Smyth, H.F. et al. (1949) concentrated vapor was inhaled by groups of 6 male or female rats. The test concentration was 4000 ppm (19613.27 mg/m³). Inhalations were continued for 4 hours. The observation period lasted 14 days. After the 4 hour-exposure two of six animals died. No information on clinical signs was given.
Acute dermal toxicity was determined by a method closely akin to the one-day cuff method of Draize et al. (1944) using groups of 4 male albino rabbits (Smyth, H.F. et al, 1949). The fur was removed by clipping and the dose was retained beneath an impervious plastic film (i.e. occlusive). The animals were immobilized/exposed for 24 hours. Afterwards, the film was removed and the animals were observed for 14 days. An LD50 value of 10.0 ml/kg bw (ca. 8276 mg/kg bw) was established. No information on clinical signs was given.
Justification for classification or non-classification
Based on the results, the test item is no subject to classification and labelling according to Regulation (EC) No 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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