Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-632-7 | CAS number: 108-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Reliable study results are available from 7 long-term studies with Daphnia magna or Ceriodaphnia dubia. The NOEC or EC10 values of the seven studies were in the range between 0.05 and 2.38 mg phenol/L. The EC10 of 0.46 mg phenol/L, obtained in a 16 day study for growth of D. magna under semi-static conditions, was selected as key information.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.46 mg/L
Additional information
Data on long term toxicity of phenol on aquatic invertebrates is presented in EU RAR (2006) in Section 3.2.1 (Aquatic compartment (incl. Sediment), page 36ff). It is stated that the lowest long-term effect value was found forDaphnia magnaby Deneer et al. (1988) for growth reduction as test parameter. Although this parameter is not a standardised endpoint the EC10-value of 0.46 mg/L will be used as long-term effect value for aquatic invertebrates.
Reliable study results are available from 7 long-term studies withDaphnia magnaorCeriodaphnia dubia. The tests were conducted under flow-through or semi-static conditions and the exposure concentrations were analytically verified in the flow-through study (Tisler & Zagorc-Koncan, 1999) and the semi-static studies of Oris et al. (1991) and SLOVNAT (2009). In the other semi-static studies the phenol concentrations are regarded as stable, since Colgan et al. (1982) and Lewis et al. (1983) demonstrated the stability of phenol under semi-static conditions. The NOEC or EC10 values of the six studies were comparable ranging between 0.46 and 2.38 mg/L.
The most reliable sensitive endpoint was the EC10 of 0.46 mg/L, based on nominal concentrations, obtained in a 16 day study withDaphnia magnaunder semi-static conditions with a 2 or 3 day renewal period (Deneer et al., 1988) according to the Dutch Standard Organisation NEN 6502 (1980). Test parameters were inhibition of length increase and reproduction of the daphnids. The most sensitive parameter was growth. As growth reduction will generally result in a lowered reproductive output, this endpoint is of high relevance. The measured EC10 of 2.38 mg/L for survival of adults and reproduction obtained in a 21 day flow-through study fulfilling the validity criteria of the OECD guideline (1982) performed by Tilser & Zagorc-Koncan (1999) are in the same order of magnitude like the EC10 of Deneer et al. (1988) and confirms their findings.
In the study of SLOVNAFT (2009), the long-term toxicity of phenol to Daphnia magna was investigated. The GLP-study was conducted according to OECD Guideline 211 (Daphnia magna Reproduction Test) for 21 d under semi-static conditions. The stability of the test solutions was investigated over a period of 5 days via TOC analysis. After 5 d 92.1% of the initial test substance concentration was found. Therefore the effect values refer to nominal concentrations. The 21 d NOEC, EC10, and EC50 based on reproduction were determined to be <0.1, 0.05, and 0.48 mg/L nominal, respectively. This study is regarded as valid with some restrictions: the extrapolated EC10 is below the lowest applied test substance concentration; toxicity results determined for the reference substance are reported to be considerably below values in comparable tests, which may point to an extraordinary sensitivity of the used daphnia strain. Therefore, this EC10 is not regarded as key result for long-term toxicity to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.