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Diss Factsheets
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EC number: 203-632-7 | CAS number: 108-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Reliable study results are available from 8 long-term studies with six fish species. The tests were conducted under flow-through or semi-static conditions and the exposure concentrations were analytically verified in the six flow-through studies. In the semi-static tests (Verma et al. 1981, 1984) the interval for test water renewal was 24 h and the phenol concentrations are regarded as stable, since Colgan et al. (1982) demonstrated the stability of phenol under semi-static conditions (48 h interval).
The most sensitive endpoint was the NOEC of 77 µg phenol/L, based on nominal concentrations, obtained in a 60 day study with Cirrhina mrigala under semi-static conditions with a 24 hour renewal period (Verma et al 1984).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.077 mg/L
Additional information
The data on long term toxicity of phenol on fish is presented in EU RAR (2006) in Section 3.2.1 (Aquatic compartment (incl. Sediment), page 36ff).
Reliable study results are available from 8 long-term studies with six fish species. The tests were conducted under flow-through or semi-static conditions and the exposure concentrations were analytically verified in the six flow-through studies. In the semi-static tests (Verma et al. 1981, 1984) the interval for test water renewal was 24 h and the phenol concentrations are regarded as stable, since Colgan et al. (1982) demonstrated the stability of phenol under semi-static conditions (48 h interval).
The most sensitive endpoint was the NOEC of 77 µg/L, based on nominal concentrations, obtained in a 60 day study with Cirrhina mrigala under semi-static conditions with a 24 hour renewal period (Verma et al., 1984). At test end survival and wet weight of the surviving larvae was recorded. Based on these results a MATC of 77 - 94 µg/L was found and a NOEC of 77 µg/L was derived. This NOEC obtained with larvae of Cirrhina mrigala is confirmed by the 60 d NOEC of 110 µg/L obtained with Cyprinus carpio from the same authors (Verma et al., 1981).
The very sensitive embryo-larval tests conducted from Birge et al. (1979) and Black et al. (1982, 1983) had been evaluated and discussed within the framework of the EU RAR (2006) and it was decided by the EU member states not to use these data for a derivation of a PNECaqua if other valid fish early life stage tests are available. Following the discussions and conclusions of the EU RAR regarding the studies of Birge et al. and Black et al., they were not considered in the current hazard assessment.
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