Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-778-1 | CAS number: 7726-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
- Principles of method if other than guideline:
- A single application patch test was conducted in rabbits to assess dermal corrosivity mitigation of bromine neat and in solution. Skin sites were exposed to bromine uncovered until evaporated (30 to 45 seconds), under plastic covering for one minute, washed off with acetone in 5 seconds after exposure, or applied uncovered as a 10% solution in methylene chloride.
Test material
- Reference substance name:
- Bromine
- EC Number:
- 231-778-1
- EC Name:
- Bromine
- Cas Number:
- 7726-95-6
- Molecular formula:
- Br2
- IUPAC Name:
- dibromine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- other: open and closed
- Preparation of test site:
- other: intact skin
- Vehicle:
- other: neat or as 10% solution in methylene chloride
- Duration of treatment / exposure:
- Until evaporated, 1 minute under plastic, for 5 seconds until washed with acetone, or until solution evaporated
- Observation period:
- Short term
Results and discussion
In vivo
- Irritant / corrosive response data:
- See table in Other Information Section. All neat applications of bromine produced necrosis. Occlusion increased severity and shortened time to appearance. 10% bromine in a methylene chloride solution produced only redness if allowed to evaporate uncovered, but caused moderate necrosis with a 1 minute occlusive exposure. Bromine chloride produced the same responses as bromine.
Any other information on results incl. tables
Rabbit Skin Irritation/Corrosion Test
Test Material |
Skin Preparation |
Duration of Exposure |
Response/Remarks |
Bromine |
Intact |
Until Evaporated (30-45 seconds) |
Short contact of less than 1 minute produced severe necrosis. Appearance of tissue reaction seems to be delayed. |
Bromine |
Intact |
1 minute covered with plastic |
Short contact of 1 minute produced deep necrosis. Appearance of tissue reactin seems to be delayed. |
Bromine |
Intact |
Site washed with acetone after 5 seconds |
Short exposure of 5 seconds produced moderate necrosis. Appearance of tissue reaction seems to be delayed. |
Bromine, 10% methylene chloride solution |
Intact |
Until Evaporated (less than 10 seconds) |
Slight hyperemia within 2 minutes |
Bromine, 10% methylene chloride solution |
Intact |
1 minute covered with plastic |
Short exposure of 1 minute produced marked necrosis. Appearance of tissue reaction seems to be delayed. |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Short term contact of bromine with intact rabbit skin for periods of less than 1 minute produced severe necrosis. Time to appearance is reduced and depth of corrosivity is enhanced with occlusion. Even wiping of the material from the skin after 5 seconds with acetone caused necrosis, although severity reduced. If bromine is applied as a 10% methylene chloride solution and allowed to evaporate (less than 10 seconds), only slight hyperemia resulted within 24 hours. When the solutions were applied and covered with plastic for one minute, marked necrosis and edema resulted. Bromine and bromine chloride produced similar results.
- Executive summary:
Bromine is a corrosive material when applied to rabbit skin for less than one minute. Even a 5 second exposure with removal by acetone wiping produces necrosis. Severity of corrosion is increased with occlusion, even in a 10% solution.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)